Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques (Q40366740)

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scientific article published on 30 September 2005

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English	Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques	scientific article published on 30 September 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 September 2017

Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques (English)

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19 September 2017

transmembrane protein

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author name string

David R Hout

1

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19 September 2017

Melissa L Gomez

2

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19 September 2017

Erik Pacyniak

3

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19 September 2017

Lisa M Gomez

4

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19 September 2017

Barbara Fegley

5

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19 September 2017

Ellyn R Mulcahy

6

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19 September 2017

M Sarah Hill

7

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19 September 2017

Nathan Culley

8

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19 September 2017

David M Pinson

9

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19 September 2017

Warren Nothnick

10

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19 September 2017

Michael F Powers

11

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19 September 2017

Scott W Wong

12

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19 September 2017

Edward B Stephens

13

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19 September 2017

language of work or name

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publication date

30 September 2005

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19 September 2017

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19 September 2017

344

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19 September 2017

2

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19 September 2017

541-559

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19 September 2017

Characterization of a novel simian immunodeficiency virus (SIVmonNG1) genome sequence from a mona monkey (Cercopithecus mona).

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Identification of a protein encoded by the vpu gene of HIV-1.

1 reference

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7 January 2021

The structure of the HIV-1 Vpu ion channel: modelling and simulation studies.

1 reference

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7 January 2021

Bundles Consisting of Extended Transmembrane Segments of Vpu from HIV-1: Computer Simulations and Conductance Measurements†

1 reference

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7 January 2021

Characterization of a novel simian immunodeficiency virus with a vpu gene from greater spot-nosed monkeys (Cercopithecus nictitans) provides new insights into simian/human immunodeficiency virus phylogeny

1 reference

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7 January 2021

Identification of a new simian immunodeficiency virus lineage with a vpu gene present among different cercopithecus monkeys (C. mona, C. cephus, and C. nictitans) from Cameroon

1 reference

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7 January 2021

Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivo

1 reference

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7 January 2021

Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.

1 reference

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7 January 2021

Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Viral ion channels: structure and function.

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7 January 2021

Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors

1 reference

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7 January 2021

Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains

1 reference

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7 January 2021

Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Molecular basis of resistance of influenza A viruses to amantadine.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Influenza virus M2 protein slows traffic along the secretory pathway. pH perturbation of acidified compartments affects early Golgi transport steps

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIV(KU-1bMC33)) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathog

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Genetic organization of a chimpanzee lentivirus related to HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Pathogenesis of SIVmac infection in Chinese and Indian rhesus macaques: effects of splenectomy on virus burden

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles?

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Molecular dynamics investigation of membrane-bound bundles of the channel-forming transmembrane domain of viral protein U from the human immunodeficiency virus HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza a virus

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Identification of a region within the cytoplasmic domain of the subtype B Vpu protein of human immunodeficiency virus type 1 (HIV-1) that is responsible for retention in the golgi complex and its absence in the Vpu protein from a subtype C HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Complete nucleotide sequence of the AIDS virus, HTLV-III

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Viral ion channels: molecular modeling and simulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Two long terminal repeat circles and persistent HIV-1 replication

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7 January 2021

Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

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7 January 2021

The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

The proteins of lymphocyte- and macrophage-tropic strains of simian immunodeficiency virus are processed differently in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

A cell-free stock of simian-human immunodeficiency virus that causes AIDS in pig-tailed macaques has a limited number of amino acid substitutions in both SIVmac and HIV-1 regions of the genome and has offered cytotropism

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Nucleotide substitutions in the long terminal repeat are not required for development of neurovirulence by simian immunodeficiency virus strain mac.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

A novel gene of HIV-1, vpu, and its 16-kilodalton product

1 reference

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7 January 2021

Roles of the histidine and tryptophan side chains in the M2 proton channel from influenza A virus

1 reference

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7 January 2021

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Structural and functional analysis of the membrane-spanning domain of the human immunodeficiency virus type 1 Vpu protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

Solution structure and orientation of the transmembrane anchor domain of the HIV-1-encoded virus protein U by high-resolution and solid-state NMR spectroscopy

1 reference

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Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression

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Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

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7 January 2021

Selective perturbation of early endosome and/or trans-Golgi network pH but not lysosome pH by dose-dependent expression of influenza M2 protein

1 reference

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7 January 2021

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: association with dementia and multinucleated giant cells in the brains of patients with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.08.022

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/J.VIROL.2005.08.022

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

ResearchGate publication ID

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