Dpp-responsive silencers are bound by a trimeric Mad-Medea complex (Q40383667)

20 September 2017

Dpp-responsive silencers are bound by a trimeric Mad-Medea complex (English)

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20 September 2017

Sheng Gao

1

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20 September 2017

Janet Steffen

series ordinal

2

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20 September 2017

Allen Laughon

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

17 August 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

43

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20 September 2017

36158-36164

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Controlling cell fate by bone morphogenetic protein receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Interaction of Smad complexes with tripartite DNA-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad4 and FAST-1 in the assembly of activin-responsive factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Nuclear interpretation of Dpp signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Schnurri mediates Dpp-dependent repression of brinker transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A niche maintaining germ line stem cells in the Drosophila ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Dpp Signaling Silences bam Transcription Directly to Establish Asymmetric Divisions of Germline Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A structural basis for mutational inactivation of the tumour suppressor Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Structural basis of Smad1 activation by receptor kinase phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Structural basis of heteromeric smad protein assembly in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Stoichiometry of active smad-transcription factor complexes on DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Drosophila glial architecture and development: analysis using a collection of new cell-specific markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Repression of dpp targets by binding of brinker to mad sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Characterization of a bone morphogenetic protein-responsive Smad-binding element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Peak levels of BMP in the Drosophila embryo control target genes by a feed-forward mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A function of CBP as a transcriptional co-activator during Dpp signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Transcriptional regulation of BMP4 synexpression in transgenic Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Schnurri interacts with Mad in a Dpp-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Crystal Structure of a Phosphorylated Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TFG-β-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506882200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506882200

1 reference

20 September 2017

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