Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif. (Q40417213)

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12 January 2020

title

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif (English)

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12 January 2020

3

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author name string

Wenge Li

1

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12 January 2020

Mohit R Jain

2

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12 January 2020

Xin Yue

4

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12 January 2020

Vidya Hebbar

5

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12 January 2020

Renping Zhou

6

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12 January 2020

A-N Tony Kong

7

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language of work or name

English

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publication date

23 May 2005

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Journal of Biological Chemistry

12 January 2020

published in

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volume

280

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12 January 2020

issue

31

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12 January 2020

page(s)

28430-28438

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

12 January 2020

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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Nrf2 is essential for protection against acute pulmonary injury in mice

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

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Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

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Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

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The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors

21 January 2018

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An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

21 January 2018

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Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

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Protein kinase cascades activated by stress and inflammatory cytokines

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Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

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The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Transport between the cell nucleus and the cytoplasm

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Identification of a signal for rapid export of proteins from the nucleus

21 January 2018

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The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

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Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

21 January 2018

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

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21 January 2018

THE HIV-1 REV PROTEIN

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CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

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Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

21 January 2018

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Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

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Cadmium Induces Nuclear Export of Bach1, a Transcriptional Repressor of Heme Oxygenase-1 Gene

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Cellular localisation and nuclear export of the human bZIP transcription factor TCF11

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Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism

21 January 2018

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Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells

21 January 2018

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21 January 2018

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

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Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

21 January 2018

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

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Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

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Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M410601200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15917227%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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