Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 (Q24563807)

Nuclear factor, erythroid derived 2, like 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Akira Kobayashi

1

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Kazuhiko Igarashi

object named as

Kazuhiko Igarashi

7

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author name string

Moon-Il Kang

2

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Hiromi Okawa

3

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Makiko Ohtsuji

4

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Yukari Zenke

5

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Tomoki Chiba

6

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Masayuki Yamamoto

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

August 2004

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published in

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volume

24

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page(s)

7130-9

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issue

16

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cites work

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The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

24 March 2017

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

7 April 2017

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

7 April 2017

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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27 September 2017

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HIF-1 and mechanisms of hypoxia sensing

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27 September 2017

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Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

27 September 2017

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The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

28 November 2018

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Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.

28 November 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=479737

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

28 November 2018

1 reference

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Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15282312

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15282312

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.24.16.7130-7139.2004

1 reference

459199

459199

1 reference

1 reference

1 reference