Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. (Q40421041)

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English	Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.	scientific article

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11 January 2020

Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor (English)

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11 January 2020

phosphorylation

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1

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author name string

Rudy L Juliano

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1 June 2005

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11 January 2020

Molecular and Cellular Biology

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11 January 2020

25

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11 January 2020

11

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11 January 2020

4466-4475

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11 January 2020

The RAF proteins take centre stage

1 reference

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22 September 2017

B-RAF is a therapeutic target in melanoma

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22 September 2017

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

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22 September 2017

Integrins regulate Rac targeting by internalization of membrane domains

1 reference

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22 September 2017

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

1 reference

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22 September 2017

Regulation of Raf through phosphorylation and N terminus-C terminus interaction

1 reference

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22 September 2017

Adhesion regulation of stromal cell-derived factor-1 activation of ERK in lymphocytes by phosphatases

1 reference

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22 September 2017

Mechanisms of regulating the Raf kinase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein

1 reference

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22 September 2017

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

1 reference

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22 September 2017

Untying the regulation of the Raf-1 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

1 reference

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22 September 2017

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

1 reference

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22 September 2017

Regulation of Raf-1 activation and signalling by dephosphorylation

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22 September 2017

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 reference

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22 September 2017

Positive and negative regulation of Raf kinase activity and function by phosphorylation

1 reference

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22 September 2017

Active Ras induces heterodimerization of cRaf and BRaf

1 reference

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22 September 2017

Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1

1 reference

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22 September 2017

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

Paxillin interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140616

22 September 2017

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

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22 September 2017

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

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22 September 2017

Isotype-specific functions of Raf kinases

1 reference

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22 September 2017

Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

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22 September 2017

Cell cycle targets of Ras/Raf signalling

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22 September 2017

Autoregulation of the Raf-1 serine/threonine kinase

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22 September 2017

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins

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22 September 2017

Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

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22 September 2017

Growth factor activation of MAP kinase requires cell adhesion.

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22 September 2017

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

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22 September 2017

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1

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22 September 2017

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

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22 September 2017

Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells

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22 September 2017

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor

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22 September 2017

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

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22 September 2017

Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

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22 September 2017

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras

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22 September 2017

Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators

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22 September 2017

The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

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22 September 2017

Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.

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25 September 2017

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

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15 June 2018

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

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Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway.

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Integrin signaling: specificity and control of cell survival and cell cycle progression

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Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras.

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Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition

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The requirement of specific membrane domains for Raf-1 phosphorylation and activation

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Mechanism of inhibition of Raf-1 by protein kinase A.

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20 August 2018

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation

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2 December 2018

Cell anchorage permits efficient signal transduction between ras and its downstream kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of BRAF(V599E) in human melanoma abrogates transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Raf-1 conserved region 2 in regulation of Ras-dependent Raf-1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function of the Rho family GTPases in Ras-stimulated Raf activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of B-Raf in Ras-induced Raf-1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the sites of interaction between c-Raf-1 and Ras-GTP

1 reference

https://pubmed.ncbi.nlm.nih.gov/15899852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.25.11.4466-4475.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899852%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899852%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899852%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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