Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2. (Q40428087)

20 September 2017

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2. (English)

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20 September 2017

Peter C W Lee

1

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20 September 2017

Navdar Sever

series ordinal

2

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20 September 2017

Russell A Debose-Boyd

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

2 May 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

26

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20 September 2017

25242-25249

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SREBPs: transcriptional mediators of lipid homeostasis

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

The sterol-sensing domain: multiple families, a unique role?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Membrane topology of human insig-1, a protein regulator of lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Transport-Dependent Proteolysis of SREBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502989200

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

21 January 2018

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Identifiers

DOI

10.1074/JBC.M502989200

1 reference

20 September 2017

1 reference