P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals (Q40428922)

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English	P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals	scientific article

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scholarly article

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Europe PubMed Central

20 September 2017

P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals (English)

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20 September 2017

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6 June 2020

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Craig P Hayes

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Barbara J Reaves

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Jeremy Sokolove

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Balázs Rada

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30 November 2016

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Journal of Immunology

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428-442

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6 June 2020

Global epidemiology of gout: prevalence, incidence and risk factors

1 reference

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21 January 2018

New-onset gout after kidney transplantation: incidence, risk factors and implications

1 reference

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21 January 2018

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines.

1 reference

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21 January 2018

Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout

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21 January 2018

Neutrophils, IL-1β, and gout: is there a link?

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21 January 2018

How to regulate neutrophils in gout

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21 January 2018

Developments in the scientific and clinical understanding of gout

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21 January 2018

The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis).

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21 January 2018

Gout-associated uric acid crystals activate the NALP3 inflammasome

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21 January 2018

The inflammasome, autoinflammatory diseases, and gout.

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21 January 2018

Beneficial suicide: why neutrophils die to make NETs

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21 January 2018

Neutrophil extracellular traps: is immunity the second function of chromatin?

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21 January 2018

Neutrophil extracellular traps kill bacteria

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21 January 2018

Novel cell death program leads to neutrophil extracellular traps

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21 January 2018

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

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21 January 2018

The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans.

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21 January 2018

Regulation of immune responses by neutrophils.

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21 January 2018

The gouty tophus: a review

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21 January 2018

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

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21 January 2018

P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals

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21 January 2018

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

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Pharmacology and structure of P2Y receptors

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Immune cell regulation by autocrine purinergic signalling

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21 January 2018

A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout

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21 January 2018

Purinergic control of neutrophil activation.

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21 January 2018

fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils.

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21 January 2018

P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells

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21 January 2018

Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP.

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21 January 2018

Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway

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21 January 2018

Distribution of P2Y6 and P2Y12 receptor: their colocalization with calbindin, calretinin and nitric oxide synthase in the guinea pig enteric nervous system

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21 January 2018

Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea

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The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP

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21 January 2018

Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation

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21 January 2018

Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps

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21 January 2018

Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation

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21 January 2018

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21 January 2018

Crystal-induced neutrophil activation

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21 January 2018

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21 January 2018

Purinergic signaling: a fundamental mechanism in neutrophil activation

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21 January 2018

P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip5I, and not by MRS-2197.

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21 January 2018

PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors

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21 January 2018

Effects of PPADS and suramin on contractions and cytoplasmic Ca2+ changes evoked by AP4A, ATP and alpha, beta-methylene ATP in guinea-pig urinary bladder

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21 January 2018

Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.

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A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis

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21 January 2018

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

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21 January 2018

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21 January 2018

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21 January 2018

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Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.

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Purinergic regulation of the immune system

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21 January 2018

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

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21 January 2018

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

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21 January 2018

P2Y6 receptor contributes to neutrophil recruitment to inflamed intestinal mucosa by increasing CXC chemokine ligand 8 expression in an AP-1-dependent manner in epithelial cells.

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21 January 2018

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21 January 2018

UDP facilitates microglial phagocytosis through P2Y6 receptors

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identifiers

10.4049/JIMMUNOL.1600766

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6 June 2020

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6 June 2020

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