Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. (Q40450776)

20 September 2017

Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. (English)

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acute promyelocytic leukemia

20 September 2017

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T Ikeda

1

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20 September 2017

F Kimura

2

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20 September 2017

Y Nakata

3

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20 September 2017

K Sato

4

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20 September 2017

K Ogura

5

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20 September 2017

K Motoyoshi

6

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20 September 2017

M Sporn

7

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20 September 2017

D Kufe

8

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20 September 2017

1 May 2005

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Cell Death & Differentiation

20 September 2017

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20 September 2017

12

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5

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20 September 2017

523-531

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401574

20 September 2017

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

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Selenoprotein expression in endothelial cells from different human vasculature and species

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A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

21 January 2018

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Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage

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Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death

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7 January 2021

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

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Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells

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Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401574

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Dimensions Publication ID

20 September 2017

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