Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. (Q40453947)

20 September 2017

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. (English)

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20 September 2017

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Jodi R Alt

1

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20 September 2017

Alyssa Bouska

2

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20 September 2017

Mario R Fernandez

3

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20 September 2017

Ronald L Cerny

4

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20 September 2017

Hua Xiao

5

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20 September 2017

Christine M Eischen

6

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20 September 2017

language of work or name

English

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publication date

25 February 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

18771-18781

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20 September 2017

19

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Direct DNA binding by Brca1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Control of apoptosis by p53.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413387200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413387200

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Overexpression of the MDM2 oncogene in leukemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The comet assay for DNA damage and repair: principles, applications, and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

DNA damage-dependent nuclear dynamics of the Mre11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Stimulation of human DNA polymerase epsilon by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Genomic instability in mice lacking histone H2AX

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413387200

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

21 January 2018

Identifiers

DOI

10.1074/JBC.M413387200

1 reference

20 September 2017

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