Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK. (Q40455785)

20 September 2017

Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK. (English)

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20 September 2017

Gretchen M Argast

1

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PubMed ID

15724446

20 September 2017

Nelson Fausto

series ordinal

2

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PubMed ID

15724446

20 September 2017

Jean S Campbell

series ordinal

3

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20 September 2017

1 January 2005

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Molecular and Cellular Biochemistry

20 September 2017

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20 September 2017

268

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20 September 2017

1-2

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20 September 2017

129-140

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https://scigraph.springernature.com/pub.10.1007/s11010-005-3701-0

20 September 2017

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cites work

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

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Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580.

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The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor

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Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha

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RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

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Inhibition of nucleoside transport by p38 MAPK inhibitors

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12 December 2020

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

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12 December 2020

Molecular basis for p38 protein kinase inhibitor specificity

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12 December 2020

Kinetic mechanism for p38 MAP kinase

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12 December 2020

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

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RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

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12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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12 December 2020

RIP2 is a Raf1-activated mitogen-activated protein kinase kinase

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12 December 2020

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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ICEBERG: a novel inhibitor of interleukin-1beta generation

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Structural basis of inhibitor selectivity in MAP kinases

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p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

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An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

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RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis

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Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase

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12 December 2020

The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.

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12 December 2020

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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12 December 2020

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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12 December 2020

CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways

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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

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12 December 2020

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

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12 December 2020

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

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12 December 2020

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

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12 December 2020

Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

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12 December 2020

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

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12 December 2020

10.1007/S11010-005-3701-0

Identifiers

DOI

1 reference

20 September 2017

1 reference

PubMed ID

15724446