2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. (Q40455972)

20 September 2017

2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. (English)

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20 September 2017

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reactive oxygen species

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3

Paul Dent

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20 September 2017

Ning Gao

1

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20 September 2017

Mohamed Rahmani

series ordinal

2

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20 September 2017

Steven Grant

series ordinal

4

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20 September 2017

language of work or name

English

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publication date

1 May 2005

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20 September 2017

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20 September 2017

24

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20 September 2017

23

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20 September 2017

3797-3809

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208530

20 September 2017

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cites work

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Mechanism of action of 2-methoxyestradiol: new developments

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22 September 2017

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22 September 2017

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Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis

22 September 2017

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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22 September 2017

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Vanadate-induced expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species

22 September 2017

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

22 September 2017

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Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells

22 September 2017

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Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

22 September 2017

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

22 September 2017

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22 September 2017

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Fundamental aspects of reactive oxygen species, or what's the matter with oxygen?

22 September 2017

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Cellular survival: a play in three Akts

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

22 September 2017

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22 September 2017

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22 September 2017

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2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta

25 September 2017

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Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

25 September 2017

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25 September 2017

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25 September 2017

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LY294002-mediated inhibition of phosphatidylinositol 3-kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos-Burkitt lymphoma B cells

25 September 2017

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The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

25 September 2017

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Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

17 June 2018

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Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.

17 June 2018

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Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner.

20 August 2018

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Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

20 August 2018

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Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition

20 August 2018

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2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production

20 August 2018

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Novel 2-methoxyestradiol analogues with antitumor activity

20 August 2018

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Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells

20 August 2018

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20 August 2018

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2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells

20 August 2018

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2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding

20 August 2018

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Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in v

20 August 2018

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Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities

20 August 2018

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2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells

20 August 2018

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p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

20 August 2018

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2-methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression.

20 August 2018

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A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress.

20 August 2018

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The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation

20 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208530

Superoxide dismutase as a target for the selective killing of cancer cells

21 January 2018

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Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin

21 January 2018

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12 December 2020

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo

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12 December 2020

Stress signals for apoptosis: ceramide and c-Jun kinase

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12 December 2020

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival

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12 December 2020

IGF-1 Regulates Cardiac Fibroblast Apoptosis Induced by Osmotic Stress

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Identifiers

DOI

10.1038/SJ.ONC.1208530

1 reference

Dimensions Publication ID

20 September 2017

0 references

1 reference

20 September 2017

1 reference