Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase. (Q40507545)

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English	Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.	scientific article

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scholarly article

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12 January 2020

Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase (English)

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12 January 2020

1 reference

dengue virus protein NS3

1 reference

based on heuristic

inferred from abstract

dengue virus protein NS5

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based on heuristic

inferred from abstract

Niklaus Mueller

3

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12 January 2020

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Changsuek Yon

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12 January 2020

Tadahisa Teramoto

2

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12 January 2020

Jessica Phelan

4

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12 January 2020

Vannakambadi K Ganesh

5

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12 January 2020

Krishna H M Murthy

6

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12 January 2020

R Padmanabhan

7

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24 May 2005

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12 January 2020

Journal of Biological Chemistry

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280

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27412-27419

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29

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12 January 2020

The molecular biology of West Nile Virus: a new invader of the western hemisphere

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Sequence analysis of cloned dengue virus type 2 genome (New Guinea-C strain).

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Molecular biology of flaviviruses

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In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids

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Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain

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Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.

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Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes

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The carboxy-terminal part of the NS 3 protein of the West Nile Flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase

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The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

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The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity

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Expression, purification, and characterization of the RNA 5'-triphosphatase activity of dengue virus type 2 nonstructural protein 3.

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Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein

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C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

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21 January 2018

The helicase from hepatitis C virus is active as an oligomer

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21 January 2018

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

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21 January 2018

ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase

1 reference

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21 January 2018

The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity

1 reference

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21 January 2018

Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro

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21 January 2018

The RNA helicase and nucleotide triphosphatase activities of the bovine viral diarrhea virus NS3 protein are essential for viral replication

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Identification and characterization of the RNA helicase activity of Japanese encephalitis virus NS3 protein

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Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5

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21 January 2018

A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'- and 3'-terminal complementary sequence motifs of the viral RNA.

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21 January 2018

Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex

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A kinetic study on the influence of the parameters in the determination of inorganic phosphate by the molybdenum blue reaction

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21 January 2018

Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

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21 January 2018

Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein

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21 January 2018

De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

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Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.

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10.1074/JBC.M501393200

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12 January 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15917225%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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