Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. (Q40514026)

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1 January 2020

title

Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells (English)

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1 January 2020

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2

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1 January 2020

author name string

Nicola J Jordan

1

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1 January 2020

Denise Barrow

3

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1 January 2020

Alan E Wakeling

4

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1 January 2020

Robert I Nicholson

5

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1 January 2020

language of work or name

English

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publication date

1 September 2004

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Breast Cancer Research and Treatment

1 January 2020

published in

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1 January 2020

volume

87

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1 January 2020

issue

2

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1 January 2020

page(s)

167-180

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https://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47

1 January 2020

exact match

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cites work

Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

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Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

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ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner

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Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer.

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7 January 2021

Inhibition of protein kinase B/Akt. implications for cancer therapy

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

Unravelling the activation mechanisms of protein kinase B/Akt

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

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7 January 2021

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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7 January 2021

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

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7 January 2021

Akt kinases in breast cancer and the results of adjuvant therapy

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Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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7 January 2021

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

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7 January 2021

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I

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7 January 2021

Heregulin regulation of Akt/protein kinase B in breast cancer cells

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7 January 2021

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7 January 2021

Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).

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7 January 2021

A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo.

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7 January 2021

Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy.

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7 January 2021

Epidermal growth factor receptor expression as a prognostic indicator in breast cancer

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7 January 2021

The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro

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7 January 2021

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

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7 January 2021

Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839).

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7 January 2021

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

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7 January 2021

The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

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7 January 2021

Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells

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7 January 2021

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell lines

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7 January 2021

Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation

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7 January 2021

Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination

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7 January 2021

The ErbB signaling network: receptor heterodimerization in development and cancer

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7 January 2021

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

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7 January 2021

Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

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7 January 2021

Role of translocation in the activation and function of protein kinase B

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7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

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7 January 2021

Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells

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7 January 2021