Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors (Q40520839)

21 September 2017

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors (English)

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21 September 2017

Zhiliang Wang

1

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21 September 2017

Michael Cuddy

2

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21 September 2017

Temesgen Samuel

3

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21 September 2017

Kate Welsh

4

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21 September 2017

Aaron Schimmer

5

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21 September 2017

Farid Hanaii

6

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21 September 2017

Richard Houghten

7

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21 September 2017

Clemencia Pinilla

8

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21 September 2017

John C Reed

9

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21 September 2017

language of work or name

English

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publication date

27 August 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

46

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21 September 2017

48168-48176

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IAP family proteins--suppressors of apoptosis

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Caspases: intracellular signaling by proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

The TNF and TNF receptor superfamilies: integrating mammalian biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Tumor necrosis factor receptor and Fas signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Transducing signals of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Caspase-12 and ER-stress-mediated apoptosis: the story so far.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

A single BIR domain of XIAP sufficient for inhibiting caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Caspase inhibitor P35 and inhibitor of apoptosis Op-IAP block in vivo proteolytic activation of an effector caspase at different steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Recruitment of octamer transcription factors to DNA by glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

BIRinging chromosomes through cell division--and survivin' the experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

KIAP, a novel member of the inhibitor of apoptosis protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Characterization of fortilin, a novel antiapoptotic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Characterization of XIAP-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Mitochondrial control of nuclear apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Detection of multiple antigens on western blots.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Structural basis of IAP recognition by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Cytochrome c: can't live with it--can't live without it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

HBXIP functions as a cofactor of survivin in apoptosis suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405022200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405022200

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21 September 2017

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