Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA. (Q40536535)

21 September 2017

title

Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA. (English)

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21 September 2017

Fumikiyo Nagawa

1

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21 September 2017

Satoshi Hirose

2

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21 September 2017

Hirofumi Nishizumi

3

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21 September 2017

Tadashi Nishihara

4

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21 September 2017

Hitoshi Sakano

5

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21 September 2017

language of work or name

English

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publication date

10 July 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

37

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21 September 2017

page(s)

38360-38368

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Somatic generation of antibody diversity

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

21 January 2018

1 reference

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Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

21 January 2018

1 reference

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

21 January 2018

1 reference

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Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

21 January 2018

1 reference

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Stimulation of V(D)J cleavage by high mobility group proteins

21 January 2018

1 reference

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V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

1 reference

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Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Functional analysis of coordinated cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

21 January 2018

1 reference

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

21 January 2018

1 reference

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

21 January 2018

1 reference

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

21 January 2018

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Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

21 January 2018

1 reference

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

A recombinase diversified: new functions of the RAG proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

DNase II: genes, enzymes and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

Cell-free V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405485200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405485200

1 reference

21 September 2017

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