Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells (Q40553357)

21 September 2017

Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells (English)

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21 September 2017

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3

Masahiko Tsujii

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21 September 2017

Hiroaki Murata

1

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21 September 2017

Shingo Tsuji

2

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21 September 2017

Yasuko Sakaguchi

4

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21 September 2017

Hai Ying Fu

5

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21 September 2017

Sunao Kawano

6

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21 September 2017

Masatsugu Hori

7

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21 September 2017

1 August 2004

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21 September 2017

Laboratory Investigation

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21 September 2017

84

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21 September 2017

1050-1059

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21 September 2017

8

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700118

21 September 2017

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Imprinted expression of the Igf2r gene depends on an intronic CpG island.

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Alterations in DNA methylation may play a variety of roles in carcinogenesis

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Cytosine methylation and human cancer

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Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element

21 January 2018

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

21 January 2018

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Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 January 2018

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Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

21 January 2018

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The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line

21 January 2018

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Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism

21 January 2018

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Role of local prostaglandin synthesis in the modulation of proliferative activity of rat colonic epithelium

21 January 2018

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Prostaglandin E2 increases growth and motility of colorectal carcinoma cells

21 January 2018

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Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

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Aspirin use and reduced risk of fatal colon cancer

21 January 2018

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DNA methylation and environmental exposures in human hepatocellular carcinoma

21 January 2018

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Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

21 January 2018

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p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

21 January 2018

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The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts

21 January 2018

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CpG-rich islands and the function of DNA methylation

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CpG islands in vertebrate genomes

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Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes

21 January 2018

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Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

21 January 2018

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Sp1 binding is inhibited by (m)Cp(m)CpG methylation.

21 January 2018

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Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

21 January 2018

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Binding of AP-1/CREB proteins and of MDBP to contiguous sites downstream of the human TGF-beta 1 gene

21 January 2018

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How does DNA methylation repress transcription?

21 January 2018

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CpG island methylator phenotype in colorectal cancer

21 January 2018

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Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

21 January 2018

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High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma

21 January 2018

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Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells

21 January 2018

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Aspirin and the Risk of Colorectal Cancer in Women

21 January 2018

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The fundamental role of epigenetic events in cancer

21 January 2018

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7 January 2021

MOLECULAR BIOLOGY:DNA Methylation de Novo

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7 January 2021

Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma

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7 January 2021

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

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7 January 2021

Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation

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7 January 2021

Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis

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7 January 2021

Inhibition of tumour growth in vivo and in vitro by prostaglandin E

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7 January 2021

Morphological Differentiation induced by Prostaglandin in Mouse Neuroblastoma Cells in Culture

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7 January 2021

Mechanism of inhibitory action of prostaglandins on the growth of human gastric carcinoma cell line KATO III

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7 January 2021

The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells

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7 January 2021

Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma

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7 January 2021

10.1038/LABINVEST.3700118

Identifiers

DOI

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21 September 2017

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