Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. (Q40553780)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15153943%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines (English)

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28 December 2019

4

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28 December 2019

author name string

N Kato

1

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28 December 2019

H Fujimoto

2

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28 December 2019

A Yoda

3

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28 December 2019

N Matsumura

5

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28 December 2019

T Kondo

6

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28 December 2019

J Tsukada

7

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28 December 2019

Y Tanaka

8

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28 December 2019

M Imamura

9

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28 December 2019

Y Minami

10

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28 December 2019

publication date

1 December 2004

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Cell Death & Differentiation

28 December 2019

published in

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28 December 2019

volume

11 Suppl 2

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28 December 2019

page(s)

S153-61

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401461

28 December 2019

exact match

0 references

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

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Chk2 activates E2F-1 in response to DNA damage

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

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Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

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Analysis of CHK2 in vulval neoplasia

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Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias

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Analysis of the CHK2 gene in lymphoid malignancies

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Mutations of Chk2 in primary hematopoietic neoplasms

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ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances

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Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage

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Characterization of tumor-associated Chk2 mutations

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CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

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Nucleolar p14(ARF) overexpression in Reed-Sternberg cells in Hodgkin's lymphoma: absence of p14(ARF)/Hdm2 complexes is associated with expression of alternatively spliced Hdm2 transcripts

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Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

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Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays

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TP53 gene mutations in Hodgkin lymphoma are infrequent and not associated with absence of Epstein-Barr virus

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

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7 January 2021

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401461

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15153943%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 December 2019

1009097402

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Fatcat ID

release_t3adxnh45rdfpb45hfgymxgmxq

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Fatcat

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24 November 2022

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