Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. (Q40555598)

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28 December 2019

title

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation (English)

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28 December 2019

2

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28 December 2019

author name string

Patrick J M Murphy

1

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28 December 2019

Yoshihiro Morishima

3

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28 December 2019

Jennifer M Harrell

4

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28 December 2019

Roland P S Kwok

5

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28 December 2019

Mats Ljungman

6

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28 December 2019

William B Pratt

7

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28 December 2019

language of work or name

English

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publication date

15 May 2004

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Journal of Biological Chemistry

28 December 2019

published in

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28 December 2019

volume

279

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28 December 2019

issue

29

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28 December 2019

page(s)

30195-30201

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Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

28 December 2019

cites work

1 reference

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21 January 2018

Surfing the p53 network

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21 January 2018

p53: good cop/bad cop.

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New approaches to understanding p53 gene tumor mutation spectra

21 January 2018

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p53 mutations in human cancers

21 January 2018

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The p53 tumour suppressor gene

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors

21 January 2018

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

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A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

21 January 2018

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Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

21 January 2018

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Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death

21 January 2018

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p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.

21 January 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

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Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

21 January 2018

1 reference

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Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus

21 January 2018

1 reference

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Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain

21 January 2018

1 reference

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The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis

21 January 2018

1 reference

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Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket

21 January 2018

1 reference

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Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton

21 January 2018

1 reference

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Nuclear protein CBP is a coactivator for the transcription factor CREB

21 January 2018

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Steroid receptor interactions with heat shock protein and immunophilin chaperones

21 January 2018

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An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones

21 January 2018

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p53 mutations in colorectal cancer

21 January 2018

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Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403539200

Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403539200

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403539200

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

21 January 2018

1 reference

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Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403539200

21 January 2018

Identifiers

DOI

10.1074/JBC.M403539200

1 reference

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28 December 2019

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