The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities (Q40559975)

21 September 2017

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities (English)

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Peter Henry St George-Hyslop

21 September 2017

Nobuo Sanjo

2

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object named as

Peter St George-Hyslop

12

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Toshitaka Kawarai

9

object named as

Toshitaka Kawarai

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21 September 2017

10

Gerold Schmitt-Ulms

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21 September 2017

Yongjun Gu

1

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21 September 2017

Fusheng Chen

3

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21 September 2017

Hiroshi Hasegawa

4

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21 September 2017

Agnes Petit

5

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21 September 2017

Xueying Ruan

6

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21 September 2017

Wenping Li

7

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21 September 2017

Cortney Shier

8

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21 September 2017

David Westaway

11

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21 September 2017

Paul E Fraser

13

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21 September 2017

language of work or name

English

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publication date

30 April 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

30

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31329-31336

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401548200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401548200

1 reference

21 September 2017

1 reference