Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. (Q40561021)

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scientific article published on 17 April 2003

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English	Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.	scientific article published on 17 April 2003

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scholarly article

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2 November 2019

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Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes (English)

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2 November 2019

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2 November 2019

Kelly J. Clemens

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2 November 2019

Jennifer L Cornish

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2 November 2019

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2 November 2019

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Iain S McGregor

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2 November 2019

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Arjan Blokland

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2 November 2019

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Clint G Gurtman

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2 November 2019

Kong M Li

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2 November 2019

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17 April 2003

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2 November 2019

Psychopharmacology

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2 November 2019

168

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2 November 2019

4

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2 November 2019

465-474

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2 November 2019

On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Psychological and physiological effects of MDMA ("Ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("ecstasy").

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Studies on the neuroprotective effect of the enantiomers of AR-A008055, a compound structurally related to clomethiazole, on MDMA ("ecstasy")-induced neurodegeneration in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance

1 reference

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12 December 2020

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Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').

1 reference

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12 December 2020

based on heuristic

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Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1 reference

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12 December 2020

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The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity

1 reference

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12 December 2020

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Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Ecstasy (MDMA): a review of its possible persistent psychological effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Ecstasy use in Australia: patterns of use and associated harm

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Retracted article on dopaminergic neurotoxicity of MDMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Potential human neurotoxicity of MDMA ('Ecstasy'): subjective self-reports, evidence from an Italian drug addiction centre and clinical case studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

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Ecstasy, 3–4 Methylenedioxymethamphetamine (MDMA), a Fatality Associated with Coagulopathy and Hyperthermia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

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Assessing antidepressant activity in rodents: recent developments and future needs

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenobarbital and dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms that are independent of thermoregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further studies of the role of hyperthermia in methamphetamine neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic modulation of the release of 5-hydroxytryptamine from the guinea pig ileum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDMA ('ecstasy') consumption in the context of polydrug abuse: a report on 150 patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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