Signalling through the insulin receptor and the insulin-like growth factor-I receptor (Q40569582)

21 September 2017

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title

Signalling through the insulin receptor and the insulin-like growth factor-I receptor (English)

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21 September 2017

E Van Obberghen

1

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21 September 2017

1 September 1994

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21 September 2017

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21 September 2017

37 Suppl 2

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21 September 2017

S125-34

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https://scigraph.springernature.com/pub.10.1007/bf00400836

21 September 2017

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cites work

Actions of insulin-like growth factors

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12 December 2020

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

1 reference

12 December 2020

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase

1 reference

12 December 2020

Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers

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12 December 2020

Activation of phosphatidylinositol 3-kinase by insulin

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12 December 2020

Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes

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12 December 2020

Signal transmission by the insulin-like growth factors

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12 December 2020

The mitogen-activated protein kinase signal transduction pathway

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12 December 2020

Signal transduction via the MAP kinases: proceed at your own RSK.

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12 December 2020

Insulin-dependent covalent reassociation of isolated alpha beta heterodimeric insulin receptors into an alpha 2 beta 2 heterotetrameric disulfide-linked complex

1 reference

12 December 2020

Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities

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12 December 2020

Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase

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12 December 2020

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

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12 December 2020

Insulin dependence of murine lymphoid T-cell leukemia

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

Oncogenes and signal transduction

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12 December 2020

Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.

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12 December 2020

Hormone binding alters the conformation of the insulin receptor

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12 December 2020

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin

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12 December 2020

Identification of determinants that confer ligand specificity on the insulin receptor

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12 December 2020

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors

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12 December 2020

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

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12 December 2020

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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12 December 2020

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors

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12 December 2020

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae

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12 December 2020

Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.

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12 December 2020

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M r 95,000 receptor subunit is its own kinase

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12 December 2020

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

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12 December 2020

Phosphorylation of the hepatic insulin receptor: stimulating effect of insulin on intact cells and in a cell-free system

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12 December 2020

The insulin receptor activation process involves localized conformational changes

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12 December 2020

Insulin Stimulates Phosphatidylinositol-3-Kinase activity in rat adipocytes

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12 December 2020

Protein serine/threonine kinases

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12 December 2020

Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase

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12 December 2020

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation

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12 December 2020

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

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12 December 2020

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro

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12 December 2020

Insulin receptor autophosphorylation occurs asymmetrically

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12 December 2020

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

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12 December 2020

Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity

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12 December 2020

Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity

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12 December 2020

Growth factor receptor tyrosine kinases

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12 December 2020

Interaction between heterologous receptor tyrosine kinases. Hormone-stimulated insulin receptors activate unoccupied IGF-I receptors.

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12 December 2020

Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase

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12 December 2020

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts

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12 December 2020

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

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12 December 2020

Conversion of phosphorylase b to phosphorylase a in muscle extracts

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12 December 2020

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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12 December 2020

Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes

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12 December 2020

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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12 December 2020

Mutations in the insulin receptor gene

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12 December 2020

The metabolic and mitogenic effects of both insulin and insulin-like growth factor are enhanced by transfection of insulin receptors into NIH3T3 fibroblasts.

1 reference

12 December 2020

Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1

1 reference

12 December 2020

The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells

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12 December 2020

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

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12 December 2020

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

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12 December 2020

Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity

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12 December 2020

Insulin and orthovanadate stimulate multiple phosphotyrosine-containing serine kinases

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12 December 2020

Protein kinase activity of the insulin receptor

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12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

Two different protein kinase activities are associated with the insulin receptor

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12 December 2020

The carboxyl-terminal domain of the insulin receptor: its potential role in growth-promoting effects

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12 December 2020

Hormone-induced conformational changes in the hepatic insulin receptor

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12 December 2020

An endogenous substrate for the insulin receptor-associated tyrosine kinase

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12 December 2020

Insulin and tumor-promoting agent regulate an inhibitor of the 44-kDa mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1 in fibroblasts

1 reference

12 December 2020

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal g

1 reference

12 December 2020

Insulin binding to its receptor induces a conformational change in the receptor C-terminus

1 reference

12 December 2020

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

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12 December 2020

Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor

1 reference

12 December 2020

Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

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12 December 2020

Identifiers

DOI

10.1007/BF00400836

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21 September 2017

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PubMed ID

7821728