Proinsulin processing in the regulated and the constitutive secretory pathway (Q40569655)

21 September 2017

1 reference

title

Proinsulin processing in the regulated and the constitutive secretory pathway (English)

1 reference

21 September 2017

P A Halban

1

1 reference

21 September 2017

1 September 1994

1 reference

21 September 2017

1 reference

21 September 2017

37 Suppl 2

1 reference

21 September 2017

S65-72

1 reference

https://scigraph.springernature.com/pub.10.1007/bf00400828

21 September 2017

0 references

cites work

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

1 reference

12 December 2020

Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets

1 reference

12 December 2020

Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.

1 reference

12 December 2020

Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives

1 reference

12 December 2020

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1 reference

12 December 2020

A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase

1 reference

12 December 2020

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

1 reference

12 December 2020

Biochemical and clinical implications of proinsulin conversion intermediates

1 reference

12 December 2020

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

1 reference

12 December 2020

Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells

1 reference

12 December 2020

Prohormone convertases revealed at last

1 reference

12 December 2020

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.

1 reference

12 December 2020

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

1 reference

12 December 2020

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles

1 reference

12 December 2020

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell

1 reference

12 December 2020

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

1 reference

12 December 2020

Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells

1 reference

12 December 2020

Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

1 reference

12 December 2020

Circulating proinsulin-like molecules

1 reference

12 December 2020

Proteolytic processing in the biosynthesis of insulin and other proteins

1 reference

12 December 2020

Isolation and Amino-acid Sequence of β-LPH from Sheep Pituitary Glands

1 reference

12 December 2020

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

1 reference

12 December 2020

Insulin biosynthesis: evidence for a precursor

1 reference

12 December 2020

Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells

1 reference

12 December 2020

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism

1 reference

12 December 2020

Direct identification of prohormone conversion site in insulin-secreting cells

1 reference

12 December 2020

Altered glucose regulation of insulin biosynthesis in insulinoma cells: mouse beta TC3 cells secrete insulin-related peptides predominantly via a constitutive pathway

1 reference

12 December 2020

The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma

1 reference

12 December 2020

Processing of peptide precursors. Identification of a new family of mammalian proteases

1 reference

12 December 2020

Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance

1 reference

12 December 2020

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

1 reference

12 December 2020

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1 reference

12 December 2020

The internal pH and membrane potential of the insulin-secretory granule

1 reference

12 December 2020

Differential kinetics of rat insulin I and II processing in rat islets of Langerhans

1 reference

12 December 2020

Pathways of protein secretion in eukaryotes.

1 reference

12 December 2020

Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells

1 reference

12 December 2020

Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay

1 reference

12 December 2020

The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides

1 reference

12 December 2020

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1 reference

12 December 2020

Proinsulin conversion intermediates: a possible source of confusion

1 reference

12 December 2020

Sorting and processing of secretory proteins

1 reference

12 December 2020

Proinsulin trafckin and processing in the pancreatic B cell

1 reference

12 December 2020

Kinetics of proinsulin conversion in human islets

1 reference

12 December 2020

The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing

1 reference

12 December 2020

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

1 reference

12 December 2020

Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells

1 reference

12 December 2020

Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II

1 reference

12 December 2020

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

1 reference

12 December 2020

Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?

1 reference

12 December 2020

Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells

1 reference

12 December 2020

Proprotein-processing endopeptidases of the insulin secretory granule

1 reference

12 December 2020

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.

1 reference

12 December 2020

Processing of proinsulin by transfected hepatoma (FAO) cells

1 reference

12 December 2020

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00400828

1 reference

21 September 2017

1 reference

PubMed ID

7821742