Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease (Q40607421)

22 September 2017

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease (English)

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22 September 2017

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7

William M Mauck

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22 September 2017

9

M Flint Beal

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22 September 2017

David K Simon

1

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22 September 2017

Michael T Lin

2

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22 September 2017

Leiya Zheng

3

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22 September 2017

Guang-Jun Liu

4

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22 September 2017

Colette H Ahn

5

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22 September 2017

Lauren M Kim

6

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22 September 2017

Florence Twu

8

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22 September 2017

Donald R Johns

10

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22 September 2017

1 January 2004

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22 September 2017

Neurobiology of Aging

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22 September 2017

25

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22 September 2017

71-81

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22 September 2017

1

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Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Oxidants, antioxidants, and the degenerative diseases of aging

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Sequence and organization of the human mitochondrial genome

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Endogenous oxidative damage of mtDNA.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Age-dependent impairment of mitochondrial function in primate brain.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Point mutations of the mtDNA control region in normal and neurodegenerative human brains

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Evidence that two reports of mtDNA cytochrome c oxidase "mutations" in Alzheimer's disease are based on nDNA pseudogenes of recent evolutionary origin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Does oxidative damage to DNA increase with age?

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial mutational spectra in human cells and tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Preservation of midbrain catecholaminergic neurons in very old human subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

The etiology of Parkinson's disease with emphasis on the MPTP story

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Quantitative allele-specific PCR: demonstration of age-associated accumulation in human tissues of the A-->G mutation at nucleotide 3243 in mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Analysis of phylogenetically reconstructed mutational spectra in human mitochondrial DNA control region

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA: molecular fossils in the nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Somatic mutations of the mitochondrial genome in human colorectal tumours

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Threshold effect and tissue specificity. Implication for mitochondrial cytopathies

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Low mutational burden of individual acquired mitochondrial DNA mutations in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Hypervariable sites in the mtDNA control region are mutational hotspots

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Origin and functional consequences of the complex I defect in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mutational scanning of mitochondrial DNA by two-dimensional electrophoresis

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https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Muscle fibres: applications for the study of the metabolic consequences of enzyme deficiencies in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2803%2900037-X

7 January 2021

10.1016/S0197-4580(03)00037-X

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DOI

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release_qesl2ylkojempbfb2t5e3nfhxy

22 September 2017

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https://api.fatcat.wiki/v0/release/qesl2ylkojempbfb2t5e3nfhxy

24 November 2022

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