Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding (Q40613613)

22 September 2017

title

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding (English)

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22 September 2017

4

Judith Frydman

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22 September 2017

Douglas E Feldman

1

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22 September 2017

Christoph Spiess

series ordinal

2

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22 September 2017

Daniel E Howard

series ordinal

3

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22 September 2017

publication date

1 November 2003

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22 September 2017

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22 September 2017

volume

12

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22 September 2017

issue

5

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22 September 2017

page(s)

1213-1224

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Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

22 September 2017

cites work

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7 January 2021

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7 January 2021

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Thermodynamic stability of wild-type and mutant p53 core domain

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The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20.

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7 January 2021

Von Hippel-Lindau disease: clinical and molecular perspectives

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7 January 2021

The structural basis of protein folding and its links with human disease

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7 January 2021

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

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7 January 2021

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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7 January 2021

Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.

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7 January 2021

Macromolecular crowding: an important but neglected aspect of the intracellular environment

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7 January 2021

Multivalent binding of nonnative substrate proteins by the chaperonin GroEL.

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7 January 2021

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

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7 January 2021

Folding of newly translated proteins in vivo: the role of molecular chaperones

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7 January 2021

Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms

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7 January 2021

Functional organization of the yeast proteome by systematic analysis of protein complexes

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7 January 2021

Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity

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7 January 2021

Molecular chaperones in the cytosol: from nascent chain to folded protein

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7 January 2021

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

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7 January 2021

Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin

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7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

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Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.

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7 January 2021

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Mutational screen identifies critical amino acid residues of beta-actin mediating interaction between its folding intermediates and eukaryotic cytosolic chaperonin CCT.

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7 January 2021

The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

Contact order, transition state placement and the refolding rates of single domain proteins.

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7 January 2021

From computer simulations to human disease: emerging themes in protein folding

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7 January 2021

Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

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7 January 2021

The cytosolic class II chaperonin CCT recognizes delineated hydrophobic sequences in its target proteins

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7 January 2021

The WD repeat: a common architecture for diverse functions

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7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

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7 January 2021

In vivo newly translated polypeptides are sequestered in a protected folding environment

1 reference

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7 January 2021

10.1016/S1097-2765(03)00423-4

Identifiers

DOI

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22 September 2017

1 reference