Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45 (Q40618659)

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scientific article published on November 7, 2003

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English	Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45	scientific article published on November 7, 2003

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45 (English)

1 reference

10.1007/S00432-003-0505-Z

https://api.crossref.org/works/10.1007/S00432-003-0505-Z

30 March 2024

phosphoinositide-3 kinase inhibitor

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605879

30 March 2024

1 reference

10.1007/S00432-003-0505-Z

https://api.crossref.org/works/10.1007/S00432-003-0505-Z

30 March 2024

author name string

Mitsuhiko Osaki

1

1 reference

Europe PubMed Central

22 September 2017

Satoru Kase

2

1 reference

Europe PubMed Central

22 September 2017

Keiko Adachi

3

1 reference

Europe PubMed Central

22 September 2017

Ami Takeda

4

1 reference

Europe PubMed Central

22 September 2017

Kiyoshi Hashimoto

5

1 reference

Europe PubMed Central

22 September 2017

Hisao Ito

6

1 reference

Europe PubMed Central

22 September 2017

language of work or name

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14605879

30 March 2024

publication date

7 November 2003

1 reference

Europe PubMed Central

22 September 2017

full work available at URL

http://link.springer.com/content/pdf/10.1007/s00432-003-0505-z.pdf

Portable Document Format

1 reference

10.1007/S00432-003-0505-Z

https://api.crossref.org/works/10.1007/S00432-003-0505-Z

30 March 2024

http://link.springer.com/article/10.1007/s00432-003-0505-z/fulltext.html

1 reference

10.1007/S00432-003-0505-Z

https://api.crossref.org/works/10.1007/S00432-003-0505-Z

30 March 2024

http://link.springer.com/content/pdf/10.1007/s00432-003-0505-z

1 reference

10.1007/S00432-003-0505-Z

https://api.crossref.org/works/10.1007/S00432-003-0505-Z

30 March 2024

Journal of Cancer Research and Clinical Oncology

1 reference

Europe PubMed Central

22 September 2017

130

1 reference

Europe PubMed Central

22 September 2017

1

1 reference

Europe PubMed Central

22 September 2017

8-14

1 reference

Europe PubMed Central

22 September 2017

https://scigraph.springernature.com/pub.10.1007/s00432-003-0505-z

0 references

Translational control of p27Kip1 accumulation during the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Fas antigen and its mediation of apoptosis in human gastric cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of death receptor signals by cellular FLIP

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UICC Study Group on basic and clinical cancer research: apoptosis in normal and tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas receptor-mediated apoptosis: a clinical application?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single BIR domain of XIAP sufficient for inhibiting caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of inhibitory nuclear factor-kappaB (NFkappaB)-independent NFkappaB activation in the gonadotropic regulation of X-linked inhibitor of apoptosis expression during ovarian follicular development in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter methylation and silencing of PTEN in gastric carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis by death factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Akt in growth and survival of PANC-1 pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular survival: a play in three Akts

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt is more than just a Bad kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of cellular apoptotic potential: contributions to oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of tumor suppressor protein PTEN during renal carcinogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas gene mutations in prostatic intraepithelial neoplasia and concurrent carcinoma: analysis of laser capture microdissected specimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14605879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00432-003-0505-Z

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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