Modulation of cellular apoptotic potential: contributions to oncogenesis (Q33771748)

29 July 2017

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title

Modulation of cellular apoptotic potential: contributions to oncogenesis (English)

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29 July 2017

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V Stambolic

1

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29 July 2017

T W Mak

series ordinal

2

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29 July 2017

J R Woodgett

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

45

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29 July 2017

6094-6103

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203126

29 July 2017

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cites work

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

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Role of translocation in the activation and function of protein kinase B

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Modulation of life and death by the TNF receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Intracellular signalling: PDK1--a kinase at the hub of things

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

EGF receptor amplification and expression in human brain tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Disruption of epithelial cell-matrix interactions induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Molecular genetics of life span in C. elegans: how much does it teach us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A C. elegans mutant that lives twice as long as wild type

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Deciphering the pathways of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Germline PTEN mutations in Cowden syndrome-like families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Genetics of programmed cell death in C. elegans: past, present and future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The role of phosphoinositide 3-kinase lipid products in cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Thymic lymphoma induction by the AKT8 murine retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Genetic analysis of protein kinase B (AKT) in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Mechanisms and genes of cellular suicide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Methuselah meets diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Phosphoinositide 3-kinases: a conserved family of signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Programmed cell death in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Stress signals for apoptosis: ceramide and c-Jun kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Caspases: the proteases of the apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Worm longevity gene cloned

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

The correction for bias in prevalence estimation with screening tests.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203126

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203126

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference