Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway (Q40641258)

22 September 2017

Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway (English)

1 reference

22 September 2017

1 reference

Yunpeng Sun

1

1 reference

22 September 2017

Chonglin Tao

2

1 reference

22 September 2017

Xiaming Huang

3

1 reference

22 September 2017

Han He

4

1 reference

22 September 2017

Hongqi Shi

5

1 reference

22 September 2017

Qiyu Zhang

6

1 reference

22 September 2017

Huanhuan Wu

7

1 reference

22 September 2017

language of work or name

English

0 references

publication date

12 May 2016

1 reference

22 September 2017

OncoTargets and Therapy

1 reference

22 September 2017

9

1 reference

22 September 2017

2845-2853

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

22 September 2017

start time

1 May 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

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miR-23a and miR-27a promote human granulosa cell apoptosis by targeting SMAD5.

22 September 2017

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Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review).

22 September 2017

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Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling

22 September 2017

1 reference

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Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus

22 September 2017

1 reference

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MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway

22 September 2017

1 reference

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Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4.

22 September 2017

1 reference

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Upregulation of microRNA-23a regulates proliferation and apoptosis by targeting APAF-1 in laryngeal carcinoma

22 September 2017

1 reference

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MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1.

22 September 2017

1 reference

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Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells

22 September 2017

1 reference

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Oncogenic miR-23a in Pancreatic Ductal Adenocarcinogenesis Via Inhibiting APAF1.

22 September 2017

1 reference

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Interplay of estrogen receptors and FOXA factors in the liver cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.

22 September 2017

1 reference

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Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers

22 September 2017

1 reference

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Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells

22 September 2017

1 reference

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Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

AMPK at the nexus of energetics and aging.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Cardiac hypertrophy is positively regulated by MicroRNA miR-23a.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Primary liver cancer: worldwide incidence and trends

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869652

Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27274280

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2147/OTT.S99770

1 reference

22 September 2017

1 reference

22 September 2017

1 reference