Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons (Q40646200)

22 September 2017

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons (English)

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22 September 2017

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7

Nahum Sonenberg

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22 September 2017

Shahab Uddin

2

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Eleanor N. Fish

9

object named as

Eleanor N Fish

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22 September 2017

Fatima Lekmine

1

1 reference

22 September 2017

Antonella Sassano

3

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22 September 2017

Simrit Parmar

4

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22 September 2017

Saskia M Brachmann

5

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22 September 2017

Beata Majchrzak

6

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22 September 2017

Nissim Hay

8

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22 September 2017

Leonidas C Platanias

10

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22 September 2017

language of work or name

English

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publication date

20 May 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

27772-27780

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22 September 2017

30

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Interferons and their actions

22 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

STATs and gene regulation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

How cells respond to interferons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Signaling pathways activated by interferons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Activation of a CrkL-stat5 signaling complex by type I interferons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Serine phosphorylation of STATs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Activation of the p38 mitogen-activated protein kinase by type I interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The p38 mitogen-activated protein kinase pathway and its role in interferon signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

S6 phosphorylation and the p70s6k/p85s6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

A quantitative three-dimensional model of the Drosophila optic lobes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Oncogenic kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301364200

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Rapamycin's resurrection: a new way to target the cancer cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

PKB binding proteins. Getting in on the Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301364200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301364200

1 reference

22 September 2017

1 reference