Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. (Q40662424)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12648450%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors (English)

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1 November 2019

4

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1 November 2019

author name string

Vivien R Sutton

series ordinal

1

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1 November 2019

Michelle E Wowk

series ordinal

2

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1 November 2019

Michael Cancilla

series ordinal

3

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1 November 2019

language of work or name

English

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publication date

1 March 2003

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1 November 2019

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1 November 2019

volume

18

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1 November 2019

issue

3

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1 November 2019

page(s)

319-329

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Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

1 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Structural basis of caspase-7 inhibition by XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Control of programmed cell death by the baculovirus genes p35 and iap.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Mitochondrial endonuclease G is important for apoptosis in C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Structural basis for the activation of human procaspase-7

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Ion channel activity of the BH3 only Bcl-2 family member, BID.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Caspase-9 can be activated without proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

A single BIR domain of XIAP sufficient for inhibiting caspases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Decreased tumor surveillance in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Caspases are not localized in mitochondria during life or death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900050-5

7 January 2021

10.1016/S1074-7613(03)00050-5

Identifiers

DOI

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1 November 2019

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