Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb. (Q40662633)

22 September 2017

Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb. (English)

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22 September 2017

Duanduan Ma

1

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22 September 2017

Ping Zhou

series ordinal

2

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22 September 2017

J William Harbour

series ordinal

3

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22 September 2017

language of work or name

English

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publication date

19 March 2003

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Journal of Biological Chemistry

22 September 2017

9

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based on heuristic

inferred from page(s)

published in

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22 September 2017

278

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22 September 2017

21

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22 September 2017

19358-19366

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The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Rb function in cell-cycle regulation and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Effects of an Rb mutation in the mouse

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M301761200

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Transducible peptide therapy for uveal melanoma and retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Mutations of the human P gene associated with Type II oculocutaneous albinism (OCA2). Mutations in brief no. 205. Online

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Domains A and B in the Rb pocket interact to form a transcriptional repressor motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Overproduction of Rb protein after the G1/S boundary causes G2 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

p53 regulation of G(2) checkpoint is retinoblastoma protein dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Hypophosphorylated retinoblastoma protein is associated with G2 arrest in esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Target gene specificity of E2F and pocket protein family members in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Twelve novel RB1 gene mutations in patients with hereditary retinoblastoma. Mutations in brief no. 206. Online

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301761200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301761200

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22 September 2017

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