Akt activation promotes degradation of tuberin and FOXO3a via the proteasome (Q40679017)

22 September 2017

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome (English)

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22 September 2017

2

Craig B Thompson

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22 September 2017

David R Plas

1

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PubMed ID

12517744

22 September 2017

language of work or name

English

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publication date

6 January 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

12361-12366

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22 September 2017

14

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Size control in animal development

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Growth factors can influence cell growth and survival through effects on glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Multisite phosphorylation and the countdown to S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Proteasome inhibitors: from research tools to drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213069200

21 January 2018

Identifiers

DOI

10.1074/JBC.M213069200

1 reference

22 September 2017

1 reference

PubMed ID

12517744