Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. (Q40686455)

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15 December 2019

title

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase (English)

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15 December 2019

7

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15 December 2019

author name string

Yuval Blat

1

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15 December 2019

Jere E Meredith

2

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15 December 2019

Qian Wang

3

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15 December 2019

Jodi D Bradley

4

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15 December 2019

Lorin A Thompson

5

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15 December 2019

Richard E Olson

6

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15 December 2019

Dietmar Seiffert

8

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15 December 2019

publication date

1 December 2002

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Biochemical and Biophysical Research Communications

15 December 2019

published in

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15 December 2019

volume

299

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15 December 2019

issue

4

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15 December 2019

page(s)

569-573

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Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin-dependent gamma-secretase activity modulates thymocyte development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

A portrait of Alzheimer secretases--new features and familiar faces

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin function: connections to Alzheimer's disease and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Identification of signal peptide peptidase, a presenilin-type aspartic protease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Signalling downstream of activated mammalian Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

The N-end rule pathway of protein degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2902705-5

10.1016/S0006-291X(02)02705-5

7 January 2021

Identifiers

DOI

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15 December 2019

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