Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells (Q40691206)

22 September 2017

Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells (English)

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22 September 2017

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6

Joseph L Witztum

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22 September 2017

Yury I Miller

1

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22 September 2017

Suganya Viriyakosol

2

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22 September 2017

Christoph J Binder

3

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22 September 2017

James R Feramisco

4

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22 September 2017

Theo N Kirkland

5

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22 September 2017

language of work or name

English

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publication date

6 November 2002

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

1561-1568

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22 September 2017

3

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Minimally modified low density lipoprotein stimulates monocyte endothelial interactions

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Atherosclerosis. the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Evidence for a role of phospholipid oxidation products in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Minimally modified low density lipoprotein is biologically active in vivo in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M209634200

Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M209634200

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Toll-like receptors and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPS-binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

A region of human CD14 required for lipopolysaccharide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

All ApoB-containing lipoproteins induce monocyte chemotaxis and adhesion when minimally modified. Modulation of lipoprotein bioactivity by platelet-activating factor acetylhydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

LPS induction of gene expression in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Soluble CD14 mediates efflux of phospholipids from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Infectious agents are not necessary for murine atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Toll-like receptors as adjuvant receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Requirement of Mitogen-Activated Protein Kinases and I B Phosphorylation for Induction of Proinflammatory Cytokines Synthesis by Macrophages Indicates Functional Similarity of Receptors Triggered by Glycosylphosphatidylinositol Anchors from Parasitic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

Toll-like Receptor 4 Polymorphisms and Atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209634200

21 January 2018

Identifiers

DOI

10.1074/JBC.M209634200

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22 September 2017

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