Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. (Q40696081)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8073946%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

review article

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title

Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8073946%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

0 references

Anderson SJ

1

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24 October 2019

Levin SD

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8073946%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Perlmutter RM

series ordinal

3

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24 October 2019

publication date

1 January 1994

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24 October 2019

published in

Advances in Immunology

1 reference

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24 October 2019

volume

56

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24 October 2019

page(s)

151-178

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Delayed thymocyte development induced by augmented expression of p56lck

24 October 2019

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Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck

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Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

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Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor

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T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck

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Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line

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An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

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7 January 2021

Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells

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7 January 2021

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7 January 2021

Profound block in thymocyte development in mice lacking p56lck

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation

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Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

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7 January 2021

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Human CD4/CD45RA+ and CD4/CD45RA- T cell subsets express CD4-p56lck complexes, CD4-associated lipid kinases, TCR/CD3-p59fyn complexes, and share similar tyrosine kinase substrates

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7 January 2021

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

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7 January 2021

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A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate

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7 January 2021

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Somatic generation of antibody diversity

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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

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7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

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7 January 2021

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

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7 January 2021

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7 January 2021

Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation

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Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

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Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor

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7 January 2021

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

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Developmental regulation of lck gene expression in T lymphocytes

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7 January 2021

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck

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7 January 2021

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

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7 January 2021

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

10.1016/S0065-2776(08)60451-4

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