Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. (Q40710176)

23 September 2017

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. (English)

1 reference

23 September 2017

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1 reference

Angela Romanelli

1

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23 September 2017

Valley C Dreisbach

series ordinal

2

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23 September 2017

John Blenis

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

14 August 2002

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

43

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23 September 2017

40281-40289

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Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Interplay between insulin and nutrients in the regulation of translation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Structural and functional analysis of pp70S6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The insulin signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Visualization of biochemical networks in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The modular phosphorylation and activation of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Dual requirement for a newly identified phosphorylation site in p70s6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205168200

21 January 2018

Identifiers

DOI

10.1074/JBC.M205168200

1 reference

23 September 2017

1 reference