Coordinate regulation of translation by the PI 3-kinase and mTOR pathways (Q34956044)

5 August 2017

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title

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways (English)

1 reference

5 August 2017

Kathleen A Martin

1

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5 August 2017

John Blenis

series ordinal

2

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5 August 2017

publication date

1 January 2002

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Advances in Cancer Research

5 August 2017

published in

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5 August 2017

volume

86

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5 August 2017

page(s)

1-39

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Atypical protein kinase Clambda binds and regulates p70 S6 kinase

5 August 2017

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase

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7 January 2021

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

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7 January 2021

Mammalian TOR: a homeostatic ATP sensor

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7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

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7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

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7 January 2021

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

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7 January 2021

Ribosomal S6 kinase signaling and the control of translation

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7 January 2021

Multiple roles for Cdc42 in cell regulation

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7 January 2021

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

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7 January 2021

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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7 January 2021

Inhibition of liver, kidney, and intestine regeneration by rapamycin

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7 January 2021

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

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7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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7 January 2021

Organization and regulation of mitogen-activated protein kinase signaling pathways

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7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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7 January 2021

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

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7 January 2021

Regulation of translation initiation by FRAP/mTOR

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7 January 2021

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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7 January 2021

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

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7 January 2021

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

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7 January 2021

The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation

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7 January 2021

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E

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7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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7 January 2021

Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase

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7 January 2021

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

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7 January 2021

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

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7 January 2021

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

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7 January 2021

Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration

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7 January 2021

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

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7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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7 January 2021

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

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7 January 2021

Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver

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7 January 2021

Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

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7 January 2021

Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis

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7 January 2021

Why cytoplasmic signalling proteins should be recruited to cell membranes.

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7 January 2021

Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

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7 January 2021

Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation

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7 January 2021

Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase

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7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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7 January 2021

Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal

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7 January 2021

Characterization of S6K2, a novel kinase homologous to S6K1

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7 January 2021

Perspectives: cell biology. All creatures great and small

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7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

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7 January 2021

Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway

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7 January 2021

Suboptimal cross-linking of antigen receptor induces Syk-dependent activation of p70S6 kinase through protein kinase C and phosphoinositol 3-kinase

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7 January 2021

A novel Cdc42Hs mutant induces cellular transformation

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7 January 2021

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

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7 January 2021

Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies

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7 January 2021

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

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PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

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7 January 2021

Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

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7 January 2021

Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation

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7 January 2021

Synthesis of the translational apparatus is regulated at the translational level

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7 January 2021

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7 January 2021

Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha

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7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

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7 January 2021

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

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7 January 2021

Drosophila S6 kinase: a regulator of cell size

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7 January 2021

Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6.

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7 January 2021

Dual requirement for a newly identified phosphorylation site in p70s6k

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7 January 2021

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

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7 January 2021

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

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7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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7 January 2021

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

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7 January 2021

A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

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7 January 2021

Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

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7 January 2021

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

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7 January 2021

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

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7 January 2021

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

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7 January 2021

Use of sirolimus in kidney transplantation

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7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

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7 January 2021

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

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7 January 2021

The guanine nucleotide-exchange factor, eIF-2B

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7 January 2021

Phosphorylation and activation of p70s6k by PDK1

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7 January 2021

Cell-cycle-dependent translational control

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7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

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7 January 2021

A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells

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7 January 2021

A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate

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7 January 2021

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

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7 January 2021

Nuclear localization of p85s6k: functional requirement for entry into S phase.

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7 January 2021

The TOR kinases link nutrient sensing to cell growth

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7 January 2021

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

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7 January 2021

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

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7 January 2021

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

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7 January 2021

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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7 January 2021

Identification of a conserved motif required for mTOR signaling

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7 January 2021

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

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7 January 2021

The role of c-myc in cellular growth control

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7 January 2021

Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.

1 reference

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7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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7 January 2021

Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes

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7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

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7 January 2021

Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

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7 January 2021

Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.

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7 January 2021

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

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7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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7 January 2021

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

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7 January 2021

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

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7 January 2021

A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

PI 3-kinase, mTOR, protein synthesis and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor

1 reference

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7 January 2021

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex

1 reference

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7 January 2021

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2986001-8

7 January 2021

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

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7 January 2021

Studies on the mechanism of resistance to rapamycin in human cancer cells

1 reference

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7 January 2021

10.1016/S0065-230X(02)86001-8

Identifiers

DOI

1 reference

5 August 2017

1 reference