Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. (Q40715808)

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scientific article published on 22 July 2002

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English	Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.	scientific article published on 22 July 2002

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11 November 2019

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway (English)

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11 November 2019

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author name string

Steven L Pelech

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11 November 2019

Raymond A Pederson

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Christopher H S McIntosh

4

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22 July 2002

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Journal of Biological Chemistry

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277

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37088-37097

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11 November 2019

The glucagon-like peptides

1 reference

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Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

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Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

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Pituitary adenylyl cyclase-activating peptide stimulates extracellular signal-regulated kinase 1 or 2 (ERK1/2) activity in a Ras-independent, mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cells.

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Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase

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Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

1 reference

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Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells

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21 January 2018

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

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Organization and regulation of mitogen-activated protein kinase signaling pathways

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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Mammalian MAP kinase signalling cascades

1 reference

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G-protein-coupled receptors and signaling networks: emerging paradigms.

1 reference

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21 January 2018

Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity

1 reference

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21 January 2018

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

1 reference

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21 January 2018

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

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Src tyrosine kinase is a novel direct effector of G proteins.

1 reference

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21 January 2018

Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells

1 reference

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21 January 2018

A family of cAMP-binding proteins that directly activate Rap1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Cyclic AMP-dependent activation of Rap1b

1 reference

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21 January 2018

RAP2B: a RAS-related GTP-binding protein from platelets

1 reference

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21 January 2018

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Regulation of Raf-1 activation and signalling by dephosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

1 reference

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21 January 2018

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

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21 January 2018

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205055200

21 January 2018

Negative regulation of Raf-1 by phosphorylation of serine 621.

1 reference

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21 January 2018

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

1 reference

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21 January 2018

beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

1 reference

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21 January 2018

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2

1 reference

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21 January 2018

Increasing cAMP attenuates activation of mitogen-activated protein kinase

1 reference

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21 January 2018

Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras.

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A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

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21 January 2018

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

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21 January 2018

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11 November 2019

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