Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. (Q40720745)

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scientific article published on July 2002

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English	Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.	scientific article published on July 2002

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Europe PubMed Central

23 September 2017

Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons (English)

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12 May 2020

author name string

Valerie Heidinger

1

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12 May 2020

Pat Manzerra

2

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12 May 2020

Xue Qing Wang

3

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12 May 2020

Uta Strasser

4

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12 May 2020

Shan-Ping Yu

5

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12 May 2020

Dennis W Choi

6

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12 May 2020

M Margarita Behrens

7

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12 May 2020

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publication date

1 July 2002

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Journal of Neuroscience

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12 May 2020

22

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12 May 2020

13

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12 May 2020

5452-5461

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12 May 2020

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

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inferred from PubMed ID database lookup

Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase

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https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

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Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition

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https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

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inferred from PubMed ID database lookup

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors.

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https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

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Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density.

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https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5

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https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of proteins in the postsynaptic density fraction by mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between metabotropic and ionotropic glutamate receptors regulates neuronal network activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal-processing machines at the postsynaptic density

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of NMDA receptor internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of dendritic spine morphology and synaptic function by Shank and Homer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptors: structure and functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of resting K+ current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A slowly inactivating potassium current in CA3 pyramidal cells of rat hippocampus in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA channel regulation by channel-associated protein tyrosine kinase Src.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gramicidin perforated patch recording and intracellular chloride activity in excitable cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/12097497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-13-05452.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758206&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758206&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758206&resulttype=core&format=json

12 May 2020

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