Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src (Q40727565)

23 September 2017

title

Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src (English)

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23 September 2017

Ken-ichi Sato

1

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23 September 2017

Tomomi Nagao

2

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23 September 2017

Miki Kakumoto

3

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23 September 2017

Miwa Kimoto

4

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23 September 2017

Tetsuji Otsuki

5

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23 September 2017

Tetsushi Iwasaki

6

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23 September 2017

Alexander A Tokmakov

7

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23 September 2017

Koji Owada

8

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23 September 2017

Yasuo Fukami

9

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23 September 2017

language of work or name

English

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publication date

4 June 2002

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

issue

33

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23 September 2017

page(s)

29568-29576

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The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

23 September 2017

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Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

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Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells

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c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

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Not all Shc's roads lead to Ras

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

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Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis

21 January 2018

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ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

21 January 2018

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Activation of the transforming potential of p60c-src by a single amino acid change

21 January 2018

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A new monoclonal antibody which selectively recognizes the active form of Src tyrosine kinase

21 January 2018

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

21 January 2018

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21 January 2018

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Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

21 January 2018

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A role for Src in signal relay by the platelet-derived growth factor alpha receptor

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SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

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Stat3 activation is required for cellular transformation by v-src

21 January 2018

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

21 January 2018

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

21 January 2018

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Tyr527 is phosphorylated in pp60c-src: implications for regulation

21 January 2018

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

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Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

21 January 2018

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

21 January 2018

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Src tyrosine kinase is a novel direct effector of G proteins.

21 January 2018

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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis

21 January 2018

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

21 January 2018

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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

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Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA

21 January 2018

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Biochemical evidence for the interaction of regulatory subunit of cAMP-dependent protein kinase with IDA (Inter-DFG-APE) region of catalytic subunit

21 January 2018

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Crystal structure of cyclin-dependent kinase 2

21 January 2018

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The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M203179200

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23 September 2017

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