Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells (Q40737376)

23 September 2017

title

Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells (English)

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23 September 2017

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Koh Katsuda

1

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23 September 2017

Masafumi Kataoka

2

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23 September 2017

Futoshi Uno

3

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23 September 2017

Takayoshi Murakami

4

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23 September 2017

Tadashi Kondo

5

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23 September 2017

Jack A Roth

6

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23 September 2017

Noriaki Tanaka

7

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23 September 2017

Toshiyoshi Fujiwara

8

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23 September 2017

language of work or name

English

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publication date

1 March 2002

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23 September 2017

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23 September 2017

volume

21

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23 September 2017

issue

13

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23 September 2017

page(s)

2108-2113

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

23 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Requirement for a functional Rb-1 gene in murine development

21 January 2018

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Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

21 January 2018

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

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Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.

21 January 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

1 reference

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Effects of an Rb mutation in the mouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner

21 January 2018

1 reference

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Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein

21 January 2018

1 reference

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Caspases: killer proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F

21 January 2018

1 reference

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Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins

21 January 2018

1 reference

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A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Adenoviral vector containing wild-type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

The caspase-RB connection in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

mdm2: a bridge over the two tumour suppressors, p53 and Rb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

The loss of mdm2 induces p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

The CDKN2A (p16) gene and human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Inhibition of apoptosis by the retinoblastoma gene product.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Expression of the cyclin‐dependent kinase inhibitors p16INK4, p15INK4B and p21Waf1/cip1 in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205272

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205272

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Dimensions Publication ID

23 September 2017

1031248355

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1 reference