Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants (Q40755915)

23 September 2017

Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants (English)

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23 September 2017

Debabrita Deb

1

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23 September 2017

Mariano Scian

2

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23 September 2017

Katherine E Roth

3

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23 September 2017

Wei Li

4

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23 September 2017

Jane Keiger

5

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23 September 2017

Abhay Sankar Chakraborti

6

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23 September 2017

Swati Palit Deb

7

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23 September 2017

Sumitra Deb

8

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23 September 2017

language of work or name

English

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publication date

1 January 2002

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23 September 2017

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23 September 2017

21

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23 September 2017

2

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23 September 2017

176-189

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205035

23 September 2017

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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Wild-type p53 can down-modulate the activity of various promoters

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

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Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

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Mdm2 promotes the rapid degradation of p53

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Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells

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p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

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Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene

21 January 2018

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p53: puzzle and paradigm

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The tumour suppressor protein p53 can repress transcription of cyclin B.

21 January 2018

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Regulation of p53 stability by Mdm2

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21 January 2018

p53 and human cancers.

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T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

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'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

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p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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The tumor suppressor genes

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p53, the cellular gatekeeper for growth and division

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The p53 tumour suppressor gene

21 January 2018

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Mutant p53 protein expression interferes with p53-independent apoptotic pathways.

21 January 2018

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Activation of p53 by oncogenes

21 January 2018

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Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

21 January 2018

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model

21 January 2018

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

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Regulation of the p53 tumor suppressor protein

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

21 January 2018

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Tumor-derived p53 mutant C174Y is a gain-of-function mutant which activates the fos promoter and enhances colony formation

21 January 2018

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How loops, beta sheets, and alpha helices help us to understand p53.

21 January 2018

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The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

21 January 2018

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The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

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Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

21 January 2018

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Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

21 January 2018

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Role of p53 family members in apoptosis

21 January 2018

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Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

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Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions

21 January 2018

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Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells

21 January 2018

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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

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21 January 2018

Surfing the p53 network

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Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

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p53 domains: identification and characterization of two autonomous DNA-binding regions.

21 January 2018

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

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Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

21 January 2018

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Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53.

21 January 2018

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

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Identification of a novel p53 functional domain that is necessary for mediating apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

21 January 2018

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7 January 2021

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

The tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Human p53 binds Holliday junctions strongly and facilitates their cleavage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Tumor suppressor p53 mutations and breast cancer: a critical analysis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205035

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205035

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Dimensions Publication ID

23 September 2017

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