Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings. (Q40786076)

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English	Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings.	scientific article

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scholarly article

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Europe PubMed Central

23 September 2017

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings (English)

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13 May 2020

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inferred from title

medicinal plant

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based on heuristic

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Nicholas Ekow Thomford

1

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13 May 2020

3

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13 May 2020

8

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13 May 2020

Ambroise Wonkam

6

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Ambroise Wonkam

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13 May 2020

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Charles Awortwe

2

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13 May 2020

Faustina Adu

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13 May 2020

Denis Chopera

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13 May 2020

Michelle Skelton

7

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13 May 2020

Collet Dandara

9

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13 May 2020

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publication date

16 February 2016

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23 September 2017

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13 May 2020

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13 May 2020

2

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13 May 2020

copyright license

Creative Commons Attribution 4.0 International

16 February 2016

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copyright status

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Herb-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity

1 reference

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12 December 2020

based on heuristic

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The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

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Herbal medicine: beneficial effects, side effects, and promising new research in the treatment of arrhythmias

1 reference

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Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

1 reference

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Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Herbal medicines for liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes.

1 reference

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The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Predicting drug-drug interactions: an FDA perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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Liver disease in the HIV-infected individual

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Biological analysis of herbal medicines used for the treatment of liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidemia and lipid management in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADME properties of herbal medicines in humans: evidence, challenges and strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidemia related to antiretroviral therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV and HAART-Associated Dyslipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quality of life in HIV/AIDS

1 reference

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High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Clinical herbal interactions with conventional drugs: from molecules to maladies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

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Herb-drug interactions and mechanistic and clinical considerations

1 reference

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12 December 2020

based on heuristic

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1 reference

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Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 2B6: function, genetics, and clinical relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

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Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC₅₀ shift

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidemia and fasting glucose impairment among HIV patients three years after the first antiretroviral regimen in a Brazilian AIDS outpatient clinic.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The co-use of conventional drugs and herbs among patients in Norwegian general practice: a cross-sectional study

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of major drug metabolizing CYPs by common herbal medicines used by HIV/AIDS patients in Africa-- implications for herb-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome p450 activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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based on heuristic

inferred from PubMed ID database lookup

Nevirapine or efavirenz for tuberculosis and HIV coinfected patients: exposure and virological failure relationship

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Managing dyslipidemia in HIV/AIDS patients: challenges and solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Bioavailability of Plant-Derived Antioxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/26891286

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based on heuristic

inferred from PubMed ID database lookup

Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds

1 reference

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Identifiers

10.3390/MOLECULES21020211

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6273559&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6273559&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6273559&resulttype=core&format=json

13 May 2020

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