The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. (Q40788805)

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English	The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.	scientific article

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22 October 2019

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential (English)

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22 October 2019

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Insulin-like receptor Dmel_CG18402

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GOA release 2020-03-11

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R Fernandez

1

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22 October 2019

D Tabarini

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22 October 2019

N Azpiazu

3

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22 October 2019

M Frasch

4

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22 October 2019

J Schlessinger

5

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1 July 1995

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22 October 2019

The EMBO Journal

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22 October 2019

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22 October 2019

3373-3384

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22 October 2019

14

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22 October 2019

SH2 and SH3 domains

1 reference

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24 September 2017

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

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24 September 2017

The insulin signaling system

1 reference

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24 September 2017

Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila

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24 September 2017

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila

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24 September 2017

Phosphatidylinositol 3-kinase

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24 September 2017

Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein

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24 September 2017

The IRS-1 signaling system

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24 September 2017

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

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24 September 2017

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

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24 September 2017

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

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24 September 2017

Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila

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24 September 2017

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

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24 September 2017

Regulation of signal transduction and signal diversity by receptor oligomerization

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24 September 2017

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

1 reference

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24 September 2017

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

1 reference

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24 September 2017

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

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24 September 2017

Monoclonal antibodies against the Drosophila nervous system

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24 September 2017

Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos

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24 September 2017

The engrailed locus of Drosophila: structural analysis of an embryonic transcript

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24 September 2017

Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster

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24 September 2017

Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells

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24 September 2017

Structure and ligand specificity of the Drosophila melanogaster insulin receptor

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24 September 2017

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody

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24 September 2017

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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24 September 2017

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

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24 September 2017

Tissue localization of Drosophila melanogaster insulin receptor transcripts during development

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24 September 2017

Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases

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24 September 2017

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies

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24 September 2017

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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24 September 2017

Splicing signals in Drosophila: intron size, information content, and consensus sequences

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24 September 2017

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals

1 reference

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24 September 2017

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase

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24 September 2017

Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis

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24 September 2017

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

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25 September 2017

Comparison of the signaling abilities of the Drosophila and human insulin receptors in mammalian cells

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25 September 2017

Mitogen-activated protein kinase activation is not sufficient for stimulation of glucose transport or glycogen synthase in 3T3-L1 adipocytes

1 reference

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15 June 2018

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport.

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Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

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15 June 2018

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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15 June 2018

Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments.

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15 June 2018

The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling.

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15 June 2018

RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.

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15 June 2018

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

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15 June 2018

Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor.

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15 June 2018

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

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15 June 2018

Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila.

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15 June 2018

A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis.

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15 June 2018

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

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15 June 2018

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors

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15 June 2018

Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin

1 reference

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15 June 2018

Dissection of the faint little ball (flb) phenotype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm

1 reference

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15 June 2018

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis.

1 reference

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15 June 2018

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1 reference

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15 June 2018

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation

1 reference

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15 June 2018

Identification of determinants that confer ligand specificity on the insulin receptor

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15 June 2018

Drosophila PS2 integrin mediates RGD-dependent cell-matrix interactions

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15 June 2018

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila

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19 August 2018

Neuroblast specification and formation regulated by wingless in the Drosophila CNS.

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19 August 2018

A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants.

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19 August 2018

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19 August 2018

spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets.

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19 August 2018

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

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19 August 2018

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies

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12 December 2020

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A phosphotyrosine interaction domain

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12 December 2020

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Insulin signalling: the role of insulin receptor substrate 1

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12 December 2020

based on heuristic

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A model for insulin binding to the insulin receptor

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

based on heuristic

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EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling

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12 December 2020

based on heuristic

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Identifiers

10.1002/J.1460-2075.1995.TB07343.X

1 reference

Europe PubMed Central

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22 October 2019

1 reference

Europe PubMed Central

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22 October 2019

1 reference

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22 October 2019

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