Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway (Q40817886)

24 September 2017

Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway (English)

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24 September 2017

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Singh LP

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24 September 2017

Gennerette D

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2

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24 September 2017

Simmons S

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3

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24 September 2017

Crook ED

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4

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24 September 2017

1 March 2001

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Journal of Diabetes and its Complications

24 September 2017

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24 September 2017

15

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24 September 2017

2

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24 September 2017

88-96

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Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity

24 September 2017

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts enhances glucose-mediated glycogen accumulation via suppression of glycogen phosphorylase activity

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Role of the glucosamine pathway in fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

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https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingd

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2800%2900140-9

7 January 2021

10.1016/S1056-8727(00)00140-9

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24 September 2017

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