Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption (Q40829094)

24 September 2017

title

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption (English)

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24 September 2017

Violette SM

1

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24 September 2017

Guan W

2

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24 September 2017

Bartlett C

3

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24 September 2017

Smith JA

4

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24 September 2017

Bardelay C

5

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24 September 2017

Antoine E

6

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24 September 2017

Rickles RJ

7

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24 September 2017

Mandine E

8

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24 September 2017

van Schravendijk MR

9

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24 September 2017

Adams SE

10

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24 September 2017

Lynch BA

11

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24 September 2017

Shakespeare WC

12

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24 September 2017

Yang M

13

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24 September 2017

Jacobsen VA

14

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24 September 2017

Takeuchi CS

15

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24 September 2017

Macek KJ

16

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24 September 2017

Bohacek RS

17

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24 September 2017

Dalgarno DC

18

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24 September 2017

Weigele M

19

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24 September 2017

Lesuisse D

20

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24 September 2017

Sawyer TK

21

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24 September 2017

Baron R

22

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24 September 2017

language of work or name

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1 January 2001

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24 September 2017

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24 September 2017

volume

28

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24 September 2017

issue

1

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24 September 2017

page(s)

54-64

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Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats

24 September 2017

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Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets

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7 January 2021

Blockade of osteoclast-mediated bone resorption through occupancy of the integrin receptor: a potential approach to the therapy of osteoporosis

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7 January 2021

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

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7 January 2021

Bisphosphonates: mechanisms of action and clinical use in osteoporosis--an update

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Localization and Characterization of the src-gene Product of Rous Sarcoma Virus

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7 January 2021

Evidence that c-src is involved in the process of osteoclastic bone resorption

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7 January 2021

Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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7 January 2021

Osteoclasts express high levels of pp60c-src in association with intracellular membranes

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7 January 2021

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

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7 January 2021

Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid

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7 January 2021

A band of F-actin containing podosomes is involved in bone resorption by osteoclasts.

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7 January 2021

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

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7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

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7 January 2021

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

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7 January 2021

A fluorescence polarization based Src-SH2 binding assay

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7 January 2021

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

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7 January 2021

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

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7 January 2021

Genetics of src: structure and functional organization of a protein tyrosine kinase

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7 January 2021

Identification of a ten-amino acid proline-rich SH3 binding site

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7 January 2021

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

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7 January 2021

A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors

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7 January 2021

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

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7 January 2021

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

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7 January 2021

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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7 January 2021

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

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7 January 2021

The many faces of Src: multiple functions of a prototypical tyrosine kinase

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7 January 2021

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

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7 January 2021

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

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7 January 2021

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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7 January 2021

Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.

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7 January 2021

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

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7 January 2021

Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption.

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7 January 2021

Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity

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7 January 2021

Cellular functions regulated by Src family kinases

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7 January 2021

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.

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7 January 2021

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells

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7 January 2021

Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70

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7 January 2021

Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo

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7 January 2021

Structural basis for the binding of proline-rich peptides to SH3 domains

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7 January 2021

NMDA channel regulation by channel-associated protein tyrosine kinase Src.

1 reference

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7 January 2021

10.1016/S8756-3282(00)00427-0

Identifiers

DOI

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24 September 2017

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