cytochrome P450 family 17 subfamily A member 1 (Q408305)

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mammalian protein found in Homo sapiens

• CYP17A1
• steroid 17-alpha-hydroxylase/17,20 lyase
• CYPXVII
• cytochrome P450 17A1
• cytochrome p450 XVIIA1
• cytochrome P450-C17
• cytochrome P450, family 17, subfamily A, polypeptide 1
• steroid 17-alpha-monooxygenase
• cytochrome P450c17
• 4.1.2.30
• 17-alpha-hydroxyprogesterone aldolase
• cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase)
• steroid 17 alpha-hydroxylase/17,20 lyase
• IPR033282

edit

Language	Label	Description	Also known as
English	cytochrome P450 family 17 subfamily A member 1	mammalian protein found in Homo sapiens	CYP17A1 steroid 17-alpha-hydroxylase/17,20 lyase CYPXVII cytochrome P450 17A1 cytochrome p450 XVIIA1 cytochrome P450-C17 cytochrome P450, family 17, subfamily A, polypeptide 1 steroid 17-alpha-monooxygenase cytochrome P450c17 4.1.2.30 17-alpha-hydroxyprogesterone aldolase cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase) steroid 17 alpha-hydroxylase/17,20 lyase IPR033282

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P05093

part of

cytochrome P450 superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P05093

cytochrome P450, E-class, group I

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P05093

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

name

P450c17 (English)

8 references

PubMed publication ID

32994263

PubMed publication ID

32084696

PubMed publication ID

31504196

PubMed publication ID

32051920

PubMed publication ID

31695722

PubMed publication ID

31495080

PubMed publication ID

31474981

PubMed publication ID

31387001

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P05093

encoded by

CYP17A1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P05093

molecular function

iron ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

oxygen binding

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Deletion of a phenylalanine in the N-terminal region of human cytochrome P-450(17 alpha) results in partial combined 17 alpha-hydroxylase/17,20-lyase deficiency

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

steroid 17-alpha-monooxygenase activity

determination method

IDA

TAS

IMP

IEA

6 references

retrieved

27 March 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

27 March 2018

stated in

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

27 March 2018

stated in

A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IMP

retrieved

27 March 2018

stated in

A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IMP

retrieved

27 March 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IEA

retrieved

27 March 2018

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IDA

monooxygenase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

heme binding

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

retrieved

8 April 2019

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IDA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

lyase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

oxidoreductase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

17-alpha-hydroxyprogesterone aldolase activity

determination method

IMP

1 reference

retrieved

27 March 2018

stated in

A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IMP

steroid 17-alpha-monooxygenase activity

determination method

IBA

IDA

IEA

IMP

TAS

7 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

8 April 2019

stated in

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

8 April 2019

stated in

A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IMP

retrieved

8 April 2019

stated in

A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

retrieved

8 April 2019

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IBA

17-alpha-hydroxyprogesterone aldolase activity

determination method

IBA

IMP

2 references

retrieved

8 April 2019

stated in

A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IBA

cell component

endoplasmic reticulum membrane

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

axon

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

neuronal cell body

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

endoplasmic reticulum

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

The genetic and functional basis of isolated 17,20-lyase deficiency

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

NAS

biological process

progesterone metabolic process

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IDA

androgen biosynthetic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

glucocorticoid biosynthetic process

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

sterol metabolic process

determination method

TAS

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

TAS

hormone biosynthetic process

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05093&geneProductId=UniProtKB:P05093

determination method

IDA

steroid biosynthetic process

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IEA

steroid metabolic process

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IDA

sex differentiation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

The genetic and functional basis of isolated 17,20-lyase deficiency

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

TAS

hormone biosynthetic process

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IBA

progesterone metabolic process

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

GOA

curator

UniProt

UniProt protein ID

P05093

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05093

determination method

IBA

physically interacts with

abiraterone

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6745

language of work or name

English

retrieved

17 August 2016

seviteronel

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL3264610

EC enzyme number

1.14.14.19

0 references

1.14.14.32

0 references

Gene Atlas image

PBB GE CYP17A1 205502 at fs.png
732 × 530; 8 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P05093

1 reference

stated in

Identifiers.org

has part(s)

cytochrome P450, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P05093

Identifiers

CAS Registry Number

9029-67-8

0 references

RefSeq protein ID

NP_000093

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1586

UniProt protein ID

P05093

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P05093

Ensembl protein ID

ENSP00000358903

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000358903

ENSP00000491508

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000491508

ENSP00000492313

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492313

ENSP00000492539

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492539

ENSP00000492651

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492651

Freebase ID

/m/0fd94_

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

142716871

0 references

OpenAlex ID

C142716871

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

3RUK

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

3SWZ

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

4NKV

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

4NKW

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

4NKX

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

4NKY

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

4NKZ

1 reference

stated in

UniProt

UniProt protein ID

P05093

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(10 entries)

edit

• cywiki CYP17A1
• dewiki Steroid-17α-Hydroxylase
• enwiki CYP17A1
• eswiki CYP17A1
• fawiki CYP17A1
• jawiki CYP17A1
• kowiki CYP17A1
• ruwiki 17-альфа-гидроксилаза
• ukwiki CYP17A1
• zhwiki CYP17A1

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q408305&oldid=2212975964"