Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001 (Q24302773)

cytochrome P450 family 17 subfamily A member 1

ChEBI release 2020-05-28

ChEBI ID

68642

1 reference

progesterone metabolic process

GOA release 2020-03-11

1 reference

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders

GOA release 2020-03-11

1 reference

Natasha M DeVore

1

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Emily E Scott

series ordinal

2

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language of work or name

English

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publication date

2 February 2012

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published in

Nature

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volume

482

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page(s)

116-9

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issue

7383

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cites work

1 reference

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27 September 2017

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Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

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Novel P450c17 mutation H373D causing combined 17alpha-hydroxylase/17,20-lyase deficiency

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22266943

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22266943

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE10743

1 reference

Dimensions Publication ID

125165

1034289210

0 references

125165

1 reference

1 reference

1 reference