Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets (Q40837240)

24 September 2017

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title

Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets (English)

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24 September 2017

Sjöholm A

1

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24 September 2017

1 August 1998

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24 September 2017

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24 September 2017

9

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24 September 2017

1

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24 September 2017

1-13

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https://scigraph.springernature.com/pub.10.1385/endo:9:1:1

24 September 2017

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Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat islets

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The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.

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Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

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Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A.

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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Characterization of serine/threonine protein phosphatases in RINm5F insulinoma cells

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Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

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Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

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Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion

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Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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Metabolic effects and fate of succinate esters in pancreatic islets

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Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets

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The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositoltrisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets

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12 December 2020

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

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12 December 2020

Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration

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12 December 2020

Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues

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12 December 2020

Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets

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12 December 2020

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12 December 2020

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12 December 2020

Nutrient regulation of insulin gene expression.

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Disordered metabolism in diabetes: have we underemphasized the fat component?

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12 December 2020

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Expression and role of ionotropic glutamate receptors in pancreatic islet cells

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12 December 2020

Age-dependent expression of protein kinase C isoforms in rat islets

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12 December 2020

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

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Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity

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Cyclic ADP-ribose in beta cells

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12 December 2020

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Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

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Inhibition of Phosphatases and Increased Ca2+ Channel Activity by Inositol Hexakisphosphate

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Protein kinase C and the regulation of insulin secretion from pancreatic B cells

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12 December 2020

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

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12 December 2020

Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats

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A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

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12 December 2020

Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.

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12 December 2020

Sulfhydryl oxidation induces rapid and reversible closure of the ATP-regulated K+ channel in the pancreatic beta-cell

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12 December 2020

Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion

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12 December 2020

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets

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12 December 2020

The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro

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12 December 2020

Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion

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12 December 2020

Thiols and pancreatic beta-cell function: a review

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12 December 2020

Lithium increases DNA replication, polyamine content, and insulin secretion by rat pancreatic beta-cells

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12 December 2020

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12 December 2020

The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release

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12 December 2020

Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide.

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12 December 2020

Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus

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12 December 2020

Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats

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12 December 2020

Banting lecture 1990. Beta-cells in type II diabetes mellitus

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12 December 2020

Cytoplasmic Ca2+ oscillations in pancreatic beta-cells.

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12 December 2020

Prolactin treatment increases GLUT2 but not the G protein subunit content in cell membranes from cultured neonatal rat islets

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12 December 2020

Respiratory, ionic, and functional effects of succinate esters in pancreatic islets.

1 reference

12 December 2020

Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic islets

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12 December 2020

Heterotrimeric G proteins: organizers of transmembrane signals

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12 December 2020

Glucose cycling in islets from healthy and diabetic rats

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12 December 2020

Cytosolic biosynthesis of GTP and ATP in normal rat pancreatic islets

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12 December 2020

Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity.

1 reference

12 December 2020

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

1 reference

12 December 2020

Cyclic ADP-ribose in insulin secretion from pancreatic beta cells.

1 reference

12 December 2020

Regulation of insulin release by calcium

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12 December 2020

Glyceraldehyde phosphate and methyl esters of succinic acid. Two "new" potent insulin secretagogues

1 reference

12 December 2020

Identification of the calmodulin-regulated protein phosphatase, calcineurin, in rat pancreatic islets

1 reference

12 December 2020

Inhibition of serine/threonine protein phosphatases promotes opening of voltage-activated L-type Ca2+ channels in insulin-secreting cells

1 reference

12 December 2020

Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells

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12 December 2020

Use of a high voltage technique to determine the molecular requirements for exocytosis in islet cells

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12 December 2020

Ceramide: an intracellular signal for apoptosis

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12 December 2020

Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.

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12 December 2020

Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets

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12 December 2020

Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta

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12 December 2020

Two signaling pathways, from the upper glycolytic flux and from the mitochondria, converge to potentiate insulin release

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12 December 2020

Characterization of the inositol 1,4,5-trisphosphate-induced Ca2+ release in pancreatic beta-cells

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12 December 2020

Metabolic coupling factors in pancreatic beta-cell signal transduction

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12 December 2020

Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).

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12 December 2020

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

12 December 2020

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

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12 December 2020

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

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12 December 2020

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

1 reference

12 December 2020

Intracellular signal transduction pathways that control pancreatic beta-cell proliferation

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12 December 2020

G proteins and modulation of insulin secretion

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12 December 2020

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

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12 December 2020

Stimulation by D-glucose of mitochondrial oxidative events in islet cells

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12 December 2020

Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus

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12 December 2020

Amplification of insulin secretion by lipid messengers

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12 December 2020

Calmodulin Activation of Adenylate Cyclase in Pancreatic Islets

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12 December 2020

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma

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12 December 2020

Proinsulin trafckin and processing in the pancreatic B cell

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12 December 2020

A possible role for glucose metabolites in the regulation of inositol-1,4,5-trisphosphate 5-phosphomonoesterase activity in pancreatic islets

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12 December 2020

Prostaglandins inhibit pancreatic beta-cell replication and long-term insulin secretion by pertussis toxin-insensitive mechanisms but do not mediate the actions of interleukin-1 beta

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12 December 2020

Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells

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12 December 2020

Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C

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12 December 2020

What if Minkowski had been ageusic? An alternative angle on diabetes

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12 December 2020

Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus

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12 December 2020

Long term inhibitory effects of pancreastatin and diazepam binding inhibitor on pancreatic beta-cell deoxyribonucleic acid replication, polyamine content, and insulin secretion

1 reference

12 December 2020

Mechanisms of action of nonglucose insulin secretagogues

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12 December 2020

Redox signaling: nitrosylation and related target interactions of nitric oxide

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12 December 2020

Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice

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12 December 2020

Identification of G Protein α-Subunits in RINm5F Cells and Their Selective Interaction with Galanin Receptor

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12 December 2020

Sulfonylurea signal transduction

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12 December 2020

Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells

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12 December 2020

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids

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12 December 2020

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

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12 December 2020

GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats

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12 December 2020

Pathogenesis of NIDDM. A balanced overview

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12 December 2020

Role of polyamines in the regulation of proliferation and hormone production by insulin-secreting cells

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12 December 2020

Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

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12 December 2020

Protein kinase C and lipid signaling for sustained cellular responses

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12 December 2020

Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists

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12 December 2020

Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells

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12 December 2020

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes

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12 December 2020

Glucose metabolism, second messengers and insulin secretion

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12 December 2020

Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C

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12 December 2020

Nitric oxide: a physiologic messenger molecule

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12 December 2020

Evidence of a role for GTP in the potentiation of Ca(2+)-induced insulin secretion by glucose in intact rat islets

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12 December 2020

Glucose regulation of insulin gene expression

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12 December 2020

K+ channels: generating excitement in pancreatic beta-cells

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12 December 2020

Inhibition of fetal rat pancreatic beta-cell replication by interleukin-1 beta in vitro is not mediated through pertussis toxin-sensitive G-proteins, a decrease in cyclic AMP, or protease activation

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12 December 2020

Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse.

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12 December 2020

Bioenergetic response of pancreatic islets to stimulation by fuel molecules

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12 December 2020

Stimulus-secretion coupling in pancreatic beta cells.

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12 December 2020

Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research

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12 December 2020

Regulation of insulin release by factors that also modify glutamate dehydrogenase

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12 December 2020

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

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12 December 2020

The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies

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12 December 2020

Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat

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12 December 2020

Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells

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12 December 2020

Inositol trisphosphate and calcium signalling

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12 December 2020

Pancreatic islet glucose metabolism and regulation of insulin secretion

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12 December 2020

Mechanism of glucose-induced insulin secretion

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12 December 2020

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

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12 December 2020

Sulfonylurea receptors, ion channels, and fruit flies

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12 December 2020

New developments in the incretin concept

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12 December 2020

Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates

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12 December 2020

Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets

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12 December 2020

Diazepam binding inhibitor and the endocrine pancreas

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12 December 2020

Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM

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12 December 2020

Elusive proximal signals of beta-cells for insulin secretion

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12 December 2020

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

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12 December 2020

Phorbol ester stimulation of pancreatic β-cell replication, polyamine content and insulin secretion

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12 December 2020

Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets

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12 December 2020

Type 1 (insulin-dependent) diabetes mellitus and nitric oxide

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12 December 2020

Somatostatin inhibits insulin secretion by a G-protein-mediated decrease in Ca2+ entry through voltage-dependent Ca2+ channels in the beta cell

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12 December 2020

Regulation of guanine-nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion

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12 December 2020

Oxidation of critical cysteine residues of type I adenylyl cyclase by o-iodosobenzoate or nitric oxide reversibly inhibits stimulation by calcium and calmodulin

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12 December 2020

Identifiers

DOI

10.1385/ENDO:9:1:1

1 reference

PubMed ID

9798725

Dimensions Publication ID

24 September 2017

0 references

1 reference

PubMed ID

9798725