p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway (Q40842648)

24 September 2017

p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway (English)

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24 September 2017

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Thomas A

1

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24 September 2017

Giesler T

series ordinal

2

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24 September 2017

White E

series ordinal

3

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24 September 2017

language of work or name

English

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publication date

1 November 2000

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24 September 2017

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24 September 2017

19

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24 September 2017

46

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24 September 2017

5259-5269

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203895

24 September 2017

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cites work

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

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Identification of a mouse p21Cdc42/Rac activated kinase

21 January 2018

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The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

21 January 2018

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Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

21 January 2018

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Bcl-2 blocks p53-dependent apoptosis

21 January 2018

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

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The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes

21 January 2018

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

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Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

21 January 2018

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Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Activation of ternary complex factor Elk-1 by stress-activated protein kinases

21 January 2018

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BCL-2 family members and the mitochondria in apoptosis

21 January 2018

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Inactivation of Bcl-2 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

21 January 2018

p53: puzzle and paradigm

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21 January 2018

Regulators of cell death

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p53, the cellular gatekeeper for growth and division

21 January 2018

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A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

21 January 2018

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Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

21 January 2018

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

21 January 2018

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Apoptosis by death factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

21 January 2018

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Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Ion channel activity of the BH3 only Bcl-2 family member, BID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Emerging from the Pak: the p21-activated protein kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Life, death, and the pursuit of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Subcellular distribution and membrane association of Rho-related small GTP-binding proteins in kidney cortex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Stress-activated kinases regulate protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Mapping of a phosphorylation site in the 176R (19 kDa) early region 1B protein of human adenovirus type 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203895

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203895

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Dimensions Publication ID

24 September 2017

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