Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. (Q40845331)

24 September 2017

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. (English)

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24 September 2017

S Ries

1

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24 September 2017

C Biederer

2

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24 September 2017

D Woods

3

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24 September 2017

O Shifman

4

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24 September 2017

S Shirasawa

5

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24 September 2017

T Sasazuki

6

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24 September 2017

M McMahon

7

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24 September 2017

M Oren

8

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24 September 2017

F McCormick

9

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24 September 2017

language of work or name

English

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publication date

1 October 2000

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24 September 2017

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24 September 2017

103

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24 September 2017

321-330

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24 September 2017

2

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

24 September 2017

1 reference

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7 January 2021

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

mdm2 expression is induced by wild type p53 activity

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate. Implications for increased therapeutic ratio of low dose rate irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Splicing into senescence: the curious case of p16 and p19ARF.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Therapeutic intervention and signaling

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7 January 2021

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Signal transduction from multiple Ras effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

MDM2--arbiter of p53's destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The p53 tumour suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

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7 January 2021

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Induction of Mdm2 and enhancement of cell survival by bFGF.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

1 reference

7 January 2021

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900123-9

7 January 2021

10.1016/S0092-8674(00)00123-9

Identifiers

DOI

1 reference

24 September 2017

1 reference